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Molecular mechanisms in amyloid fibril formation
(2004-05-21)
This thesis concerns investigations on molecular processes and interactions that lead to amyloid fibril formation. Pulmonary surfactant protein C (SP-C), and a synthetic analogue thereof, SP-C(Leu), have similar properties ...
Dopamine D2 receptor G protein coupling and it's regulation
(2004-01-08)
Dopamine (DA) receptors belong to the superfamily of G protein coupled
receptors. The D2 DA receptor is negatively coupled with adenylate
cyclase via pertussis toxin sensitive (Gi/o) G proteins. In the brain the
D2 DA ...
Allergic inflammation in children with pet allergy and asthma : mechanisms, markers and clinical consequences
(2002-05-10)
Immunological background: Allergic inflammation is a multiple-step process with many actors, where eosinophils and the release of their granula proteins play an important role. The recruitment of eosinophils is a crucial ...
Nano-electrospray mass spectrometry for the analysis of neurosteroids and related molecules
(2003-03-10)
converted into their oximes which were detected as protonated molecules with 20 times higher sensitivity than the underivatised steroids. The detection limits for the oximes of 3-oxo-delta4, 20-oxo and 17-oxo steroids were 2.5, 5, and 25 pg/µL, respectively...
Vestibular control of body orientation in lamprey
(2004-03-26)
Maintenance of body orientation (postural control) is a vital motor function of the brain. The general goal of this project was to understand the organization and operation of neuronal networks responsible for postural ...
Radiologic diagnosis of appendicitis in children
(2004-04-23)
Suspected appendicitis is the most common cause of emergency abdominal surgery in children. Because of the often atypical clinical findings, the diagnosis of appendicitis is difficult and may be delayed. Perforation has ...
Detection and epidemiologic subtyping of Legionella pneumophilia using DNA-based molecular methods
(2003-11-14)
Legionella pneumophila causes 2 - 6 % of hospitalised pneumonia cases. Several community- and hospital-acquired outbreaks have been reported over the years. Legionnaires' disease (LD) or legionellosis is also a frequent ...
Identification of the common eliminated region (CER1) by the microcell hybrid based 'elimination test'
(2001-11-27)
The aim of elimination test (Et) is to identify tumor antagonizing genes
from chromosome regions that are regularly deleted in microcell hybrid
(MCH) derived tumors through serial SCID mice passages. Et so far was
focused ...
Magnetic resonance imaging in chronic Achilles tendinopathy
(2004-03-05)
The main objective of this thesis was to evaluate and monitor the morphological response following treatment interventions in patients with chronic Achilles tendinopathy by using different MRI-techniques. For this purpose. ...
Mitochondrial dysfunction and alterations of brain HMPAO SPECT in depressive disorder : perspectives on origins of 'somatization'
(2004-04-21)
A range of somatic symptoms are more common in patients with major
depression than in the general population. Similar somatic symptoms and
depression have been described in mitochondrial disorders, in which
decreased ...