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The structural diversity of lipopolysaccharides expressed by genetically defined clinical isolates of nontypeable Haemophilus influenzae
(2003-08-08)
Nontypeable Haemophilus influenzae (NTHi) is an important cause of otitis media and respiratory tract infections. Its lipopolysaccharide (LPS) molecule, an outer membrane component, is a major virulence factor of NTHi. The ...
Galanin and Leu-enkephalin in the rat : with special reference to adjuvant arthritis
(2004-05-20)
In these studies, the tissue and cellular distribution of Galanin and
Leu-enkephalin were demonstrated in normal bone and joints. Furthermore,
tissue levels of Galanin and Leuenkephalin were also studied in the
ankles ...
Protein modification with hydrophobic prenyl groups in malignant cells
(2001-10-19)
Mevalonate (MVA) is the key intermediate in the isoprene synthetic
pathway leading to the formation of a number of biologically important
lipid molecules. It is well known that inhibition of MVA synthesis blocks
the cell ...
Cryptic chromosome abnormalities in idiopathic mental retardation
(2001-12-21)
abnormalities in a significant proportion of cases with idiopathic MR.
We analyzed 111 individuals with idiopathic MR using subtelomeric FISH probes. Ten cryptic subtelomeric rearrangements were found (9%) - five de novo deletions, one unbalanced de novo...
Matrix metalloproteinases and their inhibitors in ocular neovascularization
(2004-01-30)
MMP-2 and -9 both being implicated in neovascular responses.
In the present studies the expression and role of different angiogenic factors in ocular angiogenesis of the choroid and the cornea is studied with special emphasis on the MMPs and tissue...
Human ovarian follicle recruitment : an in vitro approach
(2004-03-17)
matrix in defined media for
7 and 14 days at 37°C with 5% C02. Different culture medium supplements
were investigated including growth differentiation factor-9 (GDF-9),
8-bromo cyclic GMP (cGMP), and activin A alone or in combination with
follicle...
Crystallographic studies of enzymes involved in biosynthesis of fatty acids : beta-ketoacyl-acyl carrier protein synthase II and delta9-stearoyl-ACP desaturase
(2003-05-16)
carbon-9 and carbon-10 in stearic acid. Desaturase is known to contain a bent hydrophobic cavity, where the fatty acid substrate binds in the vicinity of a di-iron centre that is used for activation of molecular oxygen. Following reduction by ferredoxin...
Cytochrome P450 2C9 polymorphism : interindividual differences in drug metabolism and phenotyping methodology
(2002-01-25)
enzyme variant originates from the CYP2C9*1 allele, whereas CYP2C9*2 and CYP2C9*3 code for enzymes with amino acid substitutions R144C and 1359L, respectively. There is accumulating evidence that this genetic polymorphism give rise to clinically important...
Implantation : morphological and biochemical characterization of the receptive human endometrium
(2002-09-27)
and that the pinopodes regress when the progesterone levels were decreasing. The pinopodes were found mainly on days 6 to 9 after the LH surge. The progesterone receptor B level decreased in epithelial cells concomitantly with the appearance of pinopodes. This study...
Genetic and experimental studies of seasonal affective disorder and related phenotypes
(2003-03-14)
Seasonal affective disorder (SAD) is a subtype of recurrent depressive or bipolar disorder, in which episodes reoccur and remit during a particular season each year. A genetic component in vulnerability to winter SAD has ...