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Membrane protein topology : prediction, experimental mapping and genome-wide analysis
(2004-05-12)
Membrane proteins constitute a large and important class of proteins.
They are responsible for many crucial processes in living cells, and
about 25% of all proteins encoded by a typical genome are predicted to be
membrane ...
Violence in psychiatric inpatient care
(2004-03-05)
This thesis investigates incidents of violence in two psychosis wards, analyses types of violence and the staff's emotional reaction to violence, assesses a new pharmacological treatment strategy of acutely disturbed ...
Studies of genetic and environmental influences on Parkinson’s disease
(2004-01-30)
Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. Little is known about the etiology of PD. Although several PD genes are known, these are thought to be involved in ...
Intoxication of mammalian cells by the cytolethal distending toxin of Haemophilus ducreyi : a novel mechanism of action
(2001-09-14)
The cytolethal distending toxins (CDTs) are a newly described family of
bacterial protein toxins with a novel mechanism of action: DNA damage.
Haemophilus ducreyi produces a cytotoxin that belongs to this family.
This ...
Birth centre care : reproduction and infant health
(2004-04-02)
This thesis has two general aims, to investigate factors affecting
women s decision to have a second baby and to study the effect of birth
centre care on infant outcome. The specific aims were to investigate 1)
whether ...
Studies on human polyomavirus infection in immunosuppressed patients with polyoma related tumors
(2001-09-21)
Polyomaviruses are potentially oncogenic viruses, found in humans, in other mammals and in birds all over the world. The polyomaviruses that have been observed in humans are BK virus (BKV) and JC virus (JCV) as well as the ...
Malignant mesothelioma : an experimental study with emphasis on proteoglycans in mesothelial cell growth and differentiation
(2002-04-17)
Malignant mesothelioma is a highly aggressive tumor with median survival ranging from 4 to 12 months and, despite intense therapeutical efforts, it is invariably fatal. Mesothelioma cells are unique in the sense that they ...
Microfluidic analysis and parallel confocal detection of single molecules
(2003-09-12)
The detection of single molecules using confocal spectroscopy is of major interest and tremendous improvements have been made within the last decade. The underlying basics, however, a pinhole and a single excitation volume ...
A multidisciplinary system identification of the human precision grip
(2003-11-14)
This thesis focus on the unique human ability to pick up and manipulate small objects using the precision grip, i.e., the fine grip between the index finger and the thumb. This ability is formed by the interplay between ...
Linkage and association analysis in multiple sclerosis
(2001-09-03)
the possibility of locating susceptibility genes in 5p, 12q23 and 7ptr-15 (Paper I). The highest NPL score in Nordic affected sibpair families was found in 3p14-13. This region is not only formerly suggested by British and Canadian screens, but also contains...