Search
Now showing items 1-10 of 34
Molecular genetic aspects of renal cell carcinoma development
(2003-04-25)
constituted of a deletion of 3p in conventional RCC, and a ring chromosome derived from chromosome 8 in a papillary RCC. Gain of copy number were revealed on chromosomes 3, 5, 7, 8q, and 20, while the losses encompassed 3p and 17p. The SKY and CGH data suggest...
Immunological effects of interferon-beta and glatiramer acetate in multiple sclerosis
(2004-05-06)
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, which results in demyelination, axonal loss and neurological deficits. The aetiology is unknown, however, immunopathological events, ...
The importance of Escherichia coli fimbriae in urinary tract infection
(2001-11-16)
Urinary tract infection (UTI) is a major bacterial infectious disease among women. Uropathogenic Escherichia coli is the most dominant causative agent. Clinical observations indicate that repeated cystitis induces a ...
Morphological and molecular changes in developing guinea pig osteoarthritis
(2003-01-31)
Osteoarthritis (OA) - an unspecific term for late joint destruction-is one of the most common causes of pain and disability in elderly. OA is characterized by destruction of articular cartilage and insufficient tissue ...
Intoxication of mammalian cells by the cytolethal distending toxin of Haemophilus ducreyi : a novel mechanism of action
(2001-09-14)
The cytolethal distending toxins (CDTs) are a newly described family of
bacterial protein toxins with a novel mechanism of action: DNA damage.
Haemophilus ducreyi produces a cytotoxin that belongs to this family.
This ...
Drug treatment in children with focus on off-label drug use
(2010-08-06)
There is a lack of paediatric documentation concerning efficacy and
safety of many drugs, which contribute to drug use outside the terms of the product license (off-label). In the present thesis, four studies (I-IV), using ...
Local recurrence after breast conserving surgery in breast cancer
(2002-08-30)
The general aim of this thesis was to gain increased insight into the problem of local recurrences after breast conserving surgery for breast cancer. In a population-based cohort of 4,694 women with invasive breast cancer, ...
Circadian rhythm dysfunction in the suprachiasmatic nucleus : effects of Trypanosoma brucei brucei infection and inflammatory cytokines
(2001-09-21)
Alterations in the mammalian circadian pacemaker, the hypothalamic
suprachiasmatic nuclei (SCN), were studied in an experimental rat model
of African trypanosomiasis, or sleeping sickness, caused by infections
with ...
Studies on antioxidant and lipid lowering effects on human microcirculation
(2002-10-18)
In previous work from this laboratory, vital microscopy was successfully
used to study rnicrocirculatcry effects of hypercholesterolemia in a
rabbit model. Hypercholesterolemia caused a dramatic depression of the
blood ...
Molecular biology of Brouton's tyrosine kinase
(2003-11-14)
X-linked agammaglobulinemia (XLA) is caused by an arrest in the B lymphocyte differentiation. XLA patients lack mature B-cells and subsequently antibody production. The defective gene causing XLA is the BTK gene, which ...