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Membrane protein topology : prediction, experimental mapping and genome-wide analysis
(2004-05-12)
Membrane proteins constitute a large and important class of proteins.
They are responsible for many crucial processes in living cells, and
about 25% of all proteins encoded by a typical genome are predicted to be
membrane ...
CTLA-4 expression, regulation and associations in autoimmune myasthenia gravis
(2003-10-17)
expression of CTLA-4 was achieved by IFN-gamma treatment. CTLA-4 expression was induced by PMA and IFN-gamma in the monocytic cell lines U937 and THP-1. CTLA-4 engagement by antibodies inhibited cell proliferation and down-regulated expression...
Risk and resilience in children born preterm : cognitive and executive functioning at 5 1/2 years of age
(2003-11-28)
preterm infants. We studied the 5 years development in children treated and there were no significant differences between the groups in FSIQ: 93.4 vs. 89.6; VIQ 93.6 vs. 93.7 or PIQ 94.3 vs. 86.3 Overall, the differences in survival, attention...
Longitudinal studies of human papillomavirus infection : with special reference to screening for cervical cancer and treatment of CIN
(2003-10-03)
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Study I: Women treated for cervical intraepithelial neoplasi (CIN) were analysed for presence of HPV DNA by PCR and for HPV antibodies by ELISA before and 16-27 months later. 78% of the women were positive for HPV DNA before treatment. At follow-up 4...
Murine polyomavirus VP1 virus-like particles as vectors for gene therapy and as vaccines against polyomavirus infection and tumors
(2004-05-21)
Murine polyomavirus (MPyV) is a double stranded DNA virus ubiquitous in mice. The virus genome encodes for three transforming antigens that interact with the host cell machinery in order to initiate viral production. The ...
Strategies of gene and immune therapy for tumors and viral diseases
(2003-04-04)
In the treatment of tumors and viral diseases such as HIV-1 infection, immunotherapeutic strategies do not seem to have enough capacity to eradicate an already established disease. However, these strategies could play a ...
Studies on HIV-2 antibody mediated neutralisation, coreceptor usage and in vivo tropism
(2001-11-21)
promiscuous in coreceptor usage. Broadening of coreceptor usage was
not associated with disease progression. CXCR4 usage was observed for
some isolates recovered from patients with advanced disease, and appeared
to correlate with positively charged amino acid...
Hepatitis C in chronic kidney disease and kidney transplantation : with special reference to epidemiology and treatment
(2003-10-31)
Hepatitis C (HCV) is a clinical problem in infected kidney transplant patients but is also a cause of renal disease and vasculitis. Standard therapy for HCV is a combination of interferon and ribavirin. Renal patients have ...
Life without thyroid hormone receptors
(2003-08-08)
expression in the absence and activation in the presence of T3, and iii) enzymatic control of the relative concentrations of the active thyroid hormone (T3) versus prohormone (T4) through deiodinase activity. There are also target genes that respond...
11beta-Hydroxysteroid dehydrogenase type 1 as a pharmacological target in metabolic disease
(2004-04-08)
The metabolic syndrome is a collection of associated disorders, affected by lifestyle, genetic predisposition and environment, and emerges as a consequence of the Western society lifestyle. It describes a variety of ...