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Early induced immune responses : regulation of dendritic cell and NK cell functions
(2003-11-14)
The evolution of the advanced vertebrate adaptive immune system has required co-evolution of sophisticated immune regulating systems that determine immune class of cytokines, antibodies as well as effector mechanisms used ...
Mitochondrial dysfunction and alterations of brain HMPAO SPECT in depressive disorder : perspectives on origins of 'somatization'
(2004-04-21)
A range of somatic symptoms are more common in patients with major
depression than in the general population. Similar somatic symptoms and
depression have been described in mitochondrial disorders, in which
decreased ...
Elucidation of pro-apoptotic signaling induced by cisplatin
(2003-02-07)
A major clinical problem regarding treatment of malignant tumors with anticancer drugs is inherent or acquired resistance to therapy. One factor contributing to drug resistance of cancer cells is failure to undergo apoptosis. ...
Neuropeptides and spinal antinociception : studies on galanin, nociceptin and endomorphin
(2003-05-29)
Nociception and/or the sensation of pain is essential for the survival of the organism. Just as important are the antinociceptive mechanisms that reduce the nociceptive input and perceived pain. Without such mechanisms, ...
Identification of the common eliminated region (CER1) by the microcell hybrid based 'elimination test'
(2001-11-27)
The aim of elimination test (Et) is to identify tumor antagonizing genes
from chromosome regions that are regularly deleted in microcell hybrid
(MCH) derived tumors through serial SCID mice passages. Et so far was
focused ...
Sacroiliac pain-provocation testing in physiotherapy : time and force recording
(2004-08-27)
Introduction: Some of the tests used for examining pain arising from the
sacroiliac region are intended to provoke pain by using manually applied
forces. Previous reliability and validity studies of sacroiliac
pain-provocation ...
Malignant melanoma in children and adolescents
(2003-05-07)
The aim of the work reported in the present thesis was to investigate malignant melanoma in children and adolescents. Through epidemiological studies, we wished to investigate incidence, clinical factors and prognosis and ...
On age related changes in axons and glia of the central nervous system
(2002-08-09)
A growing body of evidence shows that phenotypic changes including axon aberrations, rather than loss of neurons, account for behavioral impairments during aging. The present thesis was undertaken to investigate the ...
Studies on autoimmune diabetes in Latvians and other populations
(2001-10-09)
IDDM is an autoimmune disease, characterized by autoimmune mediated loss of insulin secreting B- cells. GAD65 and IA-2 are major B-cell specific autoantibodies and are not found in healthy population. IDDM is associated ...
Obesity, life style and society : psychological and psychosocial factors in relation to body weight and body weight changes
(2004-04-16)
This dissertation consists of two cross-sectional population studies
(studies I and IV), and two prospective studies (studies II and III).
In study I the relative importance of obesity for self-rated health with
focus ...