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Sarcoidosis : inflammatory mechanisms and markers of activity
(2002-10-25)
Sarcoidosis is a disease characterized by an accumulation of CD4+ T-lymphocytes in affected organs. Previous findings of an association between the HLA-allele DR17 and an accumulation in bronchoalveolar lavage fluid (BALF) ...
Glucocorticoids in the development and homeostasis of T lymphocytes
(2002-05-24)
Until recently the fact that glucocorticoids (GCs) play an essential physiological role in regulation of the immune system in health and disease was not fully appreciated. The main aims of this thesis were to investigate ...
Metabolic and mitogenic transduction cascades in skeletal muscle : implications for exercise effects on glucose metabolism and gene regulation
(2003-03-06)
Level of physical activity is linked to improved glucose homeostasis. The molecular signaling mechanisms by which insulin and exercise/muscle contractions lead to increased glucose transport and metabolism and gene expression ...
Novel aspects of Na+,K+-ATPase
(2002-09-13)
activated the transcription factor NF-kappaB. The oscillations required Ca 2+ influx from extracellular space and release from intracellular stores. The IP3R, located in the ER membrane, was found to play a pivotal role in initiation and maintenance of Ca 2...
Molecular consequences of cellular UDP-glucose deficiency
(2004-05-21)
A Chinese hamster fibroblast mutant cell line, deficient in UDP-glucose (UDPG), denoted as Qc, and its counterpart cell line with normalized levels of UDPG (G3), were used to determine some molecular consequences of chronic UDPG deficiency. The UDPG...
Life without thyroid hormone receptors
(2003-08-08)
. This hormone-mediated gene regulation is a finely tuned interplay of numerous parameters. These include i) usage of several isoforms of receptors (TRa1, TRb1, TRb2, TRb3) encoded for by two distinct genes, ii) receptor-mediated repression of target gene...
Identification of the common eliminated region (CER1) by the microcell hybrid based 'elimination test'
(2001-11-27)
The aim of elimination test (Et) is to identify tumor antagonizing genes
from chromosome regions that are regularly deleted in microcell hybrid
(MCH) derived tumors through serial SCID mice passages. Et so far was
focused ...
Responsible beverage service : effects of a community action project
(2004-01-16)
Alcohol consumption at licensed premises is associated with various
problems, such as violence. In 1996, a community action program was
initiated in Stockholm targeting licensed premises. An action group
consisting of ...
The human placenta : an angiographic study
(2003-04-25)
separate vessel in 112 placentas (85 %), a fenestration in 6 (5%) and a fusion in 3 (2%). In 10 the anastomosis was absent, in five of these due to a single umbilical artery. The anastomosis was wide in placentas in which the relative area supplied by each...
Molecular biology of Brouton's tyrosine kinase
(2003-11-14)
and Tec are different. Btk preferentially phosphorylates the SH3 domain of Btk and Bmx, while Itk phosphorylated Itk and Btk SH3 domains, whereas Tec could phosphorylate the SH3 domain of Btk and Tec, but also with reduced efficiency Bmx and Itk...