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Cervical cancer in Zimbabwe : viral and host factors : studies on pathogenesis of cervical cancer in Zimbabwe with special reference to type-specific human paillomavirus (HPV) infection and human cytokine gene polymorphisms
(2003-05-14)
) but not in any polymorphisms of the TNF-alpha (-308*AG), the IFN-gamma (+874 *TA) or the polymorphisms at codons 10 and 25 of the TGF-beta1 and the occurrence of cervical cancer.
Conclusion: We present the first prevalence data on HPV types in patients...
Endocrine tumour development : with special focus on chromosome arms 1p and 11q
(2002-03-29)
. The most commonly deleted region was the 18cM interval between the markers D1S2134 and D1S1669 (1p32). Furthermore, tumours secreting dopamine had a higher frequency of LOH in the region telomeric of D1S1612 (1p36.2-ter) as compared to non...
Aspects of N-glycosylation in human IgE
(2002-02-08)
E-Fc fragments were studied by cellular and immunological methods.
Enzymatic deglycosylation of IgE revealed that N-glycosylation affects expression of epitopes in the C-epsilon-2-domain either by masking them or by stabilising their conformation. In contrast...
Autoimmune markers in autoimmune diabetes
(2003-12-19)
Type 1 diabetes mellitus (T1DM) is an autoimmune disease, characterized by autoimmune mediated loss of insulin secreting Beta-cells. The disease is associated with certain HLA class 11 haplotypes. HLA DR3-DQ2 and DR4-DQ8 are positively while DQ6...
Birth centre care : reproduction and infant health
(2004-04-02)
This thesis has two general aims, to investigate factors affecting
women s decision to have a second baby and to study the effect of birth
centre care on infant outcome. The specific aims were to investigate 1)
whether ...
Adaptation to ischemia with special emphasis on nitric oxide
(2001-08-31)
Nitric oxide (NO) may play an essential role for maintenance of cardiac function and perfusion. Endothelial dysfunction of atherosclerotic vessels may aggravate cardiac ischemia/reperfusion injury. Adaptation to ischemia ...
Resistance mechanisms for nucleoside analogues : with focus on metabolism and apoptosis
(2002-11-01)
The aim of the thesis was to elucidate the mechanisms underlying resistance to nucleoside analogues used in the treatment of leukemias, with focus on cellular metabolism and induction of apoptosis. Cladribine (CdA), ...
Bile in the oesophagus contributes to the development and complications of gastro-oesophageal reflux disease
(2002-05-10)
Objective: To clarify the relationship between duodenogastro- oesophageal reflux (DGOR) and gastro- oesophageal reflux disease (GORD) and its complications.
Methods: As persons who have had their gallbladders removed ...
The biological mechanisms in neutrophil and eosinophil adhesion and transmigration in vitro and theur relation to the inflammatory process in vivo
(2001-12-28)
spontaneous, as well as eotaxin-induced capacity to
transmigrate in vitro. This increased capacity is further enhanced within
2 hours after an allergen challenge in vivo without accompanying signs of
eosinophil activation in terms of increased PBE counts...
Nano-electrospray mass spectrometry for the analysis of neurosteroids and related molecules
(2003-03-10)
converted into their oximes which were detected as protonated molecules with 20 times higher sensitivity than the underivatised steroids. The detection limits for the oximes of 3-oxo-delta4, 20-oxo and 17-oxo steroids were 2.5, 5, and 25 pg/µL, respectively...