Search
Now showing items 1-10 of 25
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
products were more or less complex 1,3-benzoxazinones, one of which required X-ray crystallography confirm its structure. During the work on preparation of N-substituted derivatives of Aa, necessary for synthesis of 1,4-benzodiazepine-3,5-diones...
Retinoid processing in vivo : characterization and structure-function analysis of retinol dehydrogenases
(2003-05-15)
Retinoids (vitamin A derivatives) are vital nutrients that regulate a variety of physiological processes, including embryonic development, postnatal growth, reproduction, cell differentiation as well as maintenance of the ...
Nano-electrospray mass spectrometry for the analysis of neurosteroids and related molecules
(2003-03-10)
analytical methods, nano-ES mass spectrometry was applied to the characterisation of a lipophilic modulatory factor isolated from mouse brain. The factor, which activated the retinoid X receptor (RXR), was extracted from mouse brain incubates, purified...
Elucidation of pro-apoptotic signaling induced by cisplatin
(2003-02-07)
A major clinical problem regarding treatment of malignant tumors with anticancer drugs is inherent or acquired resistance to therapy. One factor contributing to drug resistance of cancer cells is failure to undergo apoptosis. ...
The human placenta : an angiographic study
(2003-04-25)
The arterial vessels from the umbilical cord spreading over the chorion and its cotyledonary branches constitute the main body of the placental vascular tree. In the present study it was visualized by angiography and related ...
Physical performance tests and spinal pain : assessing impairments and activity limitations
(2002-05-09)
Background: Long-term spinal pain is a common health problem, often leading to disabilities. There is still no general agreement on what measures to use for evaluating disability in people with spinal pain. Performance-based ...
Cholangiocarcinoma in primary sclerosing cholangitis
(2001-10-05)
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown causes closely associated with ulcerative colitis. PSC is a progressive disease leading to liver failure and need for liver transplantation. ...
Cataract from ultraviolet radiation
(2001-11-09)
Cataract is the major cause of low vision and blindness in the world.
Epidemiological and experimental studies link cataract to (solar)
ultraviolet radiation (UVR) exposure. Current safety limits of UVR
exposure are based ...
Enhancement of HIV-1 DNA immunogens
(2002-11-14)
Human immunodeficiency virus type 1 eludes control by the immune response through a high degree of variability and immune escape mechanisms. Induction of a broad specific immune response is important to clear virus-infected ...
Carbon dioxide de-airing in cardiac surgery
(2004-01-09)
Background: The risks connected with the presence of air microemboli in open-heart surgery, have recently been emphasized by reports that their number is correlated with the degree of postoperative neuropsychological ...