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Studies of leukotriene C4 synthase isoenzymes and the cysteinyl leukotrine receptors in human endothelial- and mast cells
(2003-09-19)
to the preferences of LTC4S. The rat orthologs of these enzymes were cloned and found to be highly similar to their human counterparts with amino acid identities of 86.7 %, 79.6 %, and 86.2 % for LTC4S, MGST2, and MGST3, respectively. LTC4 as well as the FLAP...
Health and quality of life during years at university : studies on their development and determinants
(2004-03-26)
Transition into and life at university represent a critical period in the formation of the life-pathways of many young adults. The aim of this thesis is to increase knowledge about the health status and quality of life of ...
The role of human papillomavirus in adenocarcinoma of the uterine cervix
(2002-05-03)
Background: Cervical carcinoma is the third most common malignant disease
in women worldwide. The absolute frequency of adenocarcinoma of cervix
uteri has increased during the last decade and accounts for about 15-20%
of ...
Evaluation of medical and/or surgical treatment of anosmia/hyposmia in association with inflammatory disease of the upper airway
(2004-05-21)
Background: There is a lack of evidence-based, prospective studies in treatment of nasal polyposis. The correlations between symptoms, polyp scores and computed tomography (CT) scans have not been studied sufficiently. ...
Experimental Chagas disease
(2003-05-14)
The main focus of this thesis was to develop and utilise experimental models using the protozoan parasite Trypanosoma cruzi. We were especially interested in studying the activation of NK cells early after T. cruzi infection ...
The biological mechanisms in neutrophil and eosinophil adhesion and transmigration in vitro and theur relation to the inflammatory process in vivo
(2001-12-28)
In inflammatory reactions, eosinophils and neutrophils constitute the
major classes of granulocytes that emigrate from the bloodstream into the
tissues. The recruitment of inflammatory cells constitutes a multi-step
process ...
Strategies of gene and immune therapy for tumors and viral diseases
(2003-04-04)
In the treatment of tumors and viral diseases such as HIV-1 infection, immunotherapeutic strategies do not seem to have enough capacity to eradicate an already established disease. However, these strategies could play a ...
Quality of life in patients with malignant blood disorders : a clinical and methodological study
(2002-10-25)
The overall aim of this thesis was to evaluate and, improve measurements of, health-related quality of life (HRQL) in patients with malignant blood disorders. Patients undergoing autologous stem cell transplantation (SCT), ...
Drug treatment in children with focus on off-label drug use
(2010-08-06)
There is a lack of paediatric documentation concerning efficacy and
safety of many drugs, which contribute to drug use outside the terms of the product license (off-label). In the present thesis, four studies (I-IV), using ...
Indoor environment and recurrent wheezing in young children
(2003-02-21)
with an increased risk of infant recurrent wheezing, OR2.2 (1.1-4.5). There was also a higher proportion of recurrent wheezing in children exposed to signs of dampness, prospectively reported by parents, OR 1.4 (0.9-2.2) or observed at home inspections 1.6 (1...