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Expression and activity of Myc network proteins during cell cycle progression and differentiation
(2004-03-05)
Transcription factors of Myc network are the key regulators of cell proliferation, cell death and differentiation. Identified as a transforming oncogene, myc is the driving force of a variety of human cancers, and inactivation ...
An epidemiologic study of epithelial ovarian malignancies : with a focus on hormone-related factors
(2003-01-03)
The main purpose of this thesis was to examine estrogen and progestin effects of hormone replacement therapy, in relation to the risk for epithelial ovarian neoplasias. Other intentions were to assess reproductive factors, ...
The GDNF-receptor GFR-alpha-1 : neural expression patterns and regulation in stroke
(2002-03-04)
Background: Neurotrophic factors in the mammalian nervous system are
important for development and survival of neurons and for maintenance and
plasticity of synaptic connections. Additionally, they have been shown ...
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
quinazolines, a type of heterocyclic compounds that is considered to be highly interesting as scaffolds for development of new drugs. When the acyl halide was a tertiary 2-haloacyl halide, the reaction instead gave 1,4-benzodiazepine-3-ones via rearrangement...
A multidisciplinary system identification of the human precision grip
(2003-11-14)
This thesis focus on the unique human ability to pick up and manipulate small objects using the precision grip, i.e., the fine grip between the index finger and the thumb. This ability is formed by the interplay between ...
The human placenta : an angiographic study
(2003-04-25)
The arterial vessels from the umbilical cord spreading over the chorion and its cotyledonary branches constitute the main body of the placental vascular tree. In the present study it was visualized by angiography and related ...
Genetic dynamics of HIV-1 : recombination, drug resistance and intrahost evolution
(2004-05-14)
A striking characteristic of HIV is the enormous capacity of genetic
variation. Frequent mutations, deletions, insertions and recombination
events create a population of genetically related but non-identical
viruses ...
New micromanipulative techniques in reproductive biology
(2003-05-07)
New micro manipulative techniques have facilitated development to help patients who suffer from infertility and spontaneous abortion, as well as those who carry severe genetic diseases and have risks of delivering an ...
Factors affecting attendance at population-based mammography screening
(2002-01-11)
the mammography register in Uppsala, the Census of 1990 and the Fertility Register (Paper IV). Multivariate analyses among 4,198 non-attenders and 38,972 attenders confirmed that non-attendance was more common among women living without a partner, and among those...
Insulin resistance, genetic variation and cytokines : associations to myocardial infarction risk
(2003-10-17)
Insulin resistance, inflammation and associated genes are considered as factors of potential importance for the pathogenesis of cardiovascular diseases, but their relationship to myocardial infarction (MI) and associated ...