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Purification, structure and function of bioactive peptides
(2004-04-02)
Peptides are vitally important molecules and many evoke cellular responses. The completion of several genome sequencing projects has revealed a number of new genes. However, as functional peptides often contain posttranslational ...
Medium chain dehydrogenases/reductases : alcohol dehydrogenases of novel types
(2003-10-03)
The medium chain dehydrogenase/reductase (MDR) superfamily is separated into at least eight families, of which the dimeric alcohol dehydrogenase (ADH) is one. Including species variants, close to 1000 MDR forms have been ...
Neuropeptides and spinal antinociception : studies on galanin, nociceptin and endomorphin
(2003-05-29)
Nociception and/or the sensation of pain is essential for the survival of the organism. Just as important are the antinociceptive mechanisms that reduce the nociceptive input and perceived pain. Without such mechanisms, ...
Retinoids in experimental neuroblastoma therapy
(2003-01-24)
Retinoids are analogues of vitamin A, with documented activity against various malignant cell types. Neuroblastoma is a childhood tumour of the sympathetic nervous system that shows a complex clinical and biological ...
Malignant melanoma in children and adolescents
(2003-05-07)
The aim of the work reported in the present thesis was to investigate malignant melanoma in children and adolescents. Through epidemiological studies, we wished to investigate incidence, clinical factors and prognosis and ...
Vestibular control of body orientation in lamprey
(2004-03-26)
Maintenance of body orientation (postural control) is a vital motor function of the brain. The general goal of this project was to understand the organization and operation of neuronal networks responsible for postural ...
Technology development for genome and polymorphism analysis
(2003-01-24)
Single nucleotide polymorphism (SNP) is widely expected to provide a multitude of benefits in areas of medical research. There is, however, a growing disparity between the rate of SNP discovery and the development of ...
Mild cognitive impairment neuroimaging markers for early diagnosis of dementia
(2003-09-12)
This thesis concerns the investigation of mild cognitive impairment (MCI) and Alzheimer's disease (AD) using single photon emission computed tomography (SPECT) and quantitative electroencepholography (qEEG).
In study ...
Physical performance tests and spinal pain : assessing impairments and activity limitations
(2002-05-09)
Background: Long-term spinal pain is a common health problem, often leading to disabilities. There is still no general agreement on what measures to use for evaluating disability in people with spinal pain. Performance-based ...
Genetic dynamics of HIV-1 : recombination, drug resistance and intrahost evolution
(2004-05-14)
A striking characteristic of HIV is the enormous capacity of genetic
variation. Frequent mutations, deletions, insertions and recombination
events create a population of genetically related but non-identical
viruses ...