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Platelet serotonin function and personality traits in affective disorder
(2002-03-29)
Serotonin (5-HT, 5-hydroxytryptamine) is a neurotransmitter in the central nervous system which has been implicated m the aetiology and pathogenesis of affective disorders like depression and anxiety disorders. The ...
Etiology of gastroesophageal reflux
(2004-04-16)
Although gastroesophageal reflux disease is among the most common disorders at all in Western populations, the etiology is largely unknown. The objective of this thesis is to increase the knowledge of the etiology of reflux ...
Surgical treatment of atrial fibrillation : clinical, hormonal and electrophysiological aspects of the maze operation
(2003-01-17)
, excessive postoperative fluid retention and damage to the cardiac conduction system.
The aims of this thesis were to: 1) Evaluate the reproducibility, safety and local clinical results of the Maze operation for treatment of symptomatic and medically...
Local recurrence after breast conserving surgery in breast cancer
(2002-08-30)
. Generally, the risk of local recurrence was higher than expected, but the estimated survival rates were gratifying. The overall risk of local recurrence was 9.2% at five years and 21.1% at ten years, and the breast cancer-specific survival was 93.3% and 85.2...
Life without thyroid hormone receptors
(2003-08-08)
. This hormone-mediated gene regulation is a finely tuned interplay of numerous parameters. These include i) usage of several isoforms of receptors (TRa1, TRb1, TRb2, TRb3) encoded for by two distinct genes, ii) receptor-mediated repression of target gene...
Extrahepatic cytochrome P450s : relation to cancer susceptibility
(2003-09-19)
in 15 samples and found enzymes involved in the metabolism of environmental carcinogens, steroid hormones and drugs. A large interindividual variation in the expression of CYP1A1, 2A6, 2B6, 2D6 and 3A were shown whereas CYP1B1, 2C, 2E 1, 4A and 19...
Perinatal HIV-1 infection : aspects on clinical presentation, viral dynamics and epidemiology
(2004-09-15)
During the last 20 years HIV-1 infection has changed from being an
unknown disease to being a widespread pandemic, in some areas affecting a
large proportion of the human population. Mother-to-child transmission
(MTCT) ...
Characterization of human chromosome 22 : cloning of breakpoints of the constitutional translocation t(11;22)(q23;q11) and detection of small constitutional delections by microarray CGH
(2003-03-26)
Chromosome 22 is the second smallest human chromosome, composing approximately 1.5% of the genome. The short arm of this acrocentric chromosome harbors ribosomal genes and the long arm contains the protein coding genes. This chromosome is gene...
Insulin resistance, genetic variation and cytokines : associations to myocardial infarction risk
(2003-10-17)
Insulin resistance, inflammation and associated genes are considered as factors of potential importance for the pathogenesis of cardiovascular diseases, but their relationship to myocardial infarction (MI) and associated ...
Concepts in DNA immunization overcoming viral diversity and enhancing plasmid immunogenicity
(2004-05-07)
immunogen is of importance for efficient induction of immunity. Further, antibody responses to a DNA immunogen can be substantially enhanced if the genetic immunogen is coupled to a carrier, in our case the polyomavirus VP1 capsid. In combination...