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Regulation and physiological role of tyrosine hydroxylase phosphorylation in the striatum
(2003-02-07)
AMP-dependent protein kinase catalysed phosphorylation of TH at Ser4O. Synthesis of striatal dopamine is controlled by dopamine D2 autoreceptors located on nigrostriatal nerve terminals.
It is demonstrated that such a control specifically involves the short isoform...
Experimental studies on endotoxin infusion in human : evaluation of pharmacological immunomodulation by adenosine and nicotinamide
(2003-11-14)
interventions and hopefully attenuate the inflammatory response.
Methods: The studies were performed using endotoxin (2-4 ng/kg BW) intravenously in healthy male volunteers and took place in the intensive care unit at Huddinge University Hospital. All...
Analyses of the expression and function of the aspartic protease napsin
(2004-04-02)
Two-dimensional gel electrophoresis (2 DE) is one of the powerful tools for the expression profiling of proteins. Using 2 DE, two polypeptides which are expressed exclusively in primary lung adenocarcinomas have been described. Mass spectrometry...
Classification and reuse of clinical information in general practice : studies on diagnostic and pharmacological information in electronic patient record systems
(2002-09-06)
The reuse of clinical information from the electronic patient record (EPR) for all health care areas - administrative, clinical, teaching and research - win constitute a challenge in coming decades. Classification and ...
The prognostic significance of uPA, uPAR an d the cytokine IL-1-alpha in urinary bladder cancer
(2002-03-22)
Tumor invasion and metastasis are the major causes of cancer-related
death. Proteases are important for the invasive and metastatic
propensities of tumors. We have studied the mechanism underlying
endogenous expression of ...
The study of the Escherichia coli BarA-UvrY two-component system and its ability to sense the environment
(2003-03-07)
A bacterium always has to be prepared for rapid changes in its environment, e.g. a varying supply of nutrients. The rapid adjustment to new conditions largely relies on two-component systems (TCSs), typically consisting ...
The human placenta : an angiographic study
(2003-04-25)
separate vessel in 112 placentas (85 %), a fenestration in 6 (5%) and a fusion in 3 (2%). In 10 the anastomosis was absent, in five of these due to a single umbilical artery. The anastomosis was wide in placentas in which the relative area supplied by each...
Hepatitis C in chronic kidney disease and kidney transplantation : with special reference to epidemiology and treatment
(2003-10-31)
Hepatitis C (HCV) is a clinical problem in infected kidney transplant patients but is also a cause of renal disease and vasculitis. Standard therapy for HCV is a combination of interferon and ribavirin. Renal patients have ...
Endocrine and metabolic aspects of adult Prader Willi syndrome with special emphasis on the effect of growth hormone treatment
(2003-09-05)
Prader Willi Syndrome (PWS) is a complex genetic disorder characterized by muscular hypotonia, hyperphagia, obesity and behavioural problems. Partial growth hormone (GH) deficiency and hypogonadism are common. Results of ...
Diagnostic evaluation of fetal death with special reference to intrauterine infections
(2002-05-10)
-99 according to an extensive investigational protocol. A presumptive explanation of the stillbirth was established in 91% of the cases. The most common factors associated with intrauterine fetal death could be identified as infections (24%), placental...