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Early detection of colorectal cancer
(2004-03-05)
This thesis addresses the early detection of colorectal cancer from several aspects. An audit of the diagnostic process was conducted in 227/235 (97%) patients with recentlydiagnosed colorectal cancer in the County of ...
Bioinformatic methods in protein characterization
(2002-11-08)
Bioinformatics is an emerging interdisciplinary research field in which mathematics. computer science and biology meet. In this thesis. bioinformatic methods for analysis of functional and structural properties among ...
DARPP-32 in the striatum : multiple regulation and physiological role
(2001-08-24)
Protein phosphorylation is an important mechanism involved in
intracellular signal transduction. The activity of many proteins is
affected by their state of phosphorylation, which in turn is determined
by the combined ...
Studies on proteins involved in the molecular regulation of insulin exocytosis
(2004-02-27)
Type 2 diabetes mellitus is a disease characterized by impaired insulin secretion and insulin resistance. Better understanding of molecular mechanisms of insulin secretion may help to optimize type 2 diabetes management. ...
Studies on the atypical orphan receptor SHP
(2001-11-23)
Nuclear receptors (NRs) comprise the largest family of transcription factors in eukaryotes and play critical roles in nearly every aspect of vertebrate development and adult physiology. In general, they function as ...
Malignant mesothelioma : an experimental study with emphasis on proteoglycans in mesothelial cell growth and differentiation
(2002-04-17)
Malignant mesothelioma is a highly aggressive tumor with median survival ranging from 4 to 12 months and, despite intense therapeutical efforts, it is invariably fatal. Mesothelioma cells are unique in the sense that they ...
Studies on the inflammatory response in experimental acute pyelonephritis and its importance for the development of renal scarring
(2002-01-08)
Acute pyelonephritis especially in childhood is a serious and globally common bacterial infection. The infecting microorganism is often derived from the patient's own bowel flora and mainly affects the renal parenchyma and ...
Radiologic diagnosis of appendicitis in children
(2004-04-23)
Suspected appendicitis is the most common cause of emergency abdominal surgery in children. Because of the often atypical clinical findings, the diagnosis of appendicitis is difficult and may be delayed. Perforation has ...
Diabetic osteopathy : a study in the rat
(2012-03-09)
The present study on non-obese Goto-Kakizaki (GK) rats with type-2 diabetes and neuropathy was an attempt to describe and define pertinent features of diabetic osteopathy. Altogether, the study included 33 GK rats aged 12 ...
Linkage and association analysis in multiple sclerosis
(2001-09-03)
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, which is characterized by relapsing or progressive demyelinating plaques in the brain and spinal cord. It is well established that ...