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Molecular biology of Brouton's tyrosine kinase
(2003-11-14)
X-linked agammaglobulinemia (XLA) is caused by an arrest in the B lymphocyte differentiation. XLA patients lack mature B-cells and subsequently antibody production. The defective gene causing XLA is the BTK gene, which codes for the protein Bruton...
In vitro fertilization : emotional reactions to treatment, pregnancy and parenthood
(2003-11-21)
The overall aim of this thesis was to study the emotional reactions of women and men entering in vitro fertilization (IVF) treatment and to study the emotional reactions during pregnancy and postpartum in couples who have ...
Magnetic resonance imaging in chronic Achilles tendinopathy
(2004-03-05)
The main objective of this thesis was to evaluate and monitor the morphological response following treatment interventions in patients with chronic Achilles tendinopathy by using different MRI-techniques. For this purpose. ...
Cholangiocarcinoma in primary sclerosing cholangitis
(2001-10-05)
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown causes closely associated with ulcerative colitis. PSC is a progressive disease leading to liver failure and need for liver transplantation. ...
Mechanisms of apoptosis induced by a protein complex isolated from human milk : with focus on the role of mitochondria
(2001-11-23)
Human milk contains a protein complex comprising of a folding variant of
human alpha-lactalbumin and oleic acid (C18:1). Both, a milk fraction
containing this complex (MAL, for multimeric (alpha- lactalbumin)., as
well ...
Perinatal HIV-1 infection : aspects on clinical presentation, viral dynamics and epidemiology
(2004-09-15)
During the last 20 years HIV-1 infection has changed from being an
unknown disease to being a widespread pandemic, in some areas affecting a
large proportion of the human population. Mother-to-child transmission
(MTCT) ...
Characterization of human chromosome 22 : cloning of breakpoints of the constitutional translocation t(11;22)(q23;q11) and detection of small constitutional delections by microarray CGH
(2003-03-26)
Chromosome 22 is the second smallest human chromosome, composing approximately 1.5% of the genome. The short arm of this acrocentric chromosome harbors ribosomal genes and the long arm contains the protein coding genes. ...
On prognostic and treatment predictive factors in early stage breast cancer
(2002-05-03)
Breast cancer is the most common malignant tumor in Swedish women and the incidence is increasing with 1-2% per year in the Stockholm area. A subgroup of patients is women diagnosed with primary inoperable disease. This ...
Regulation of p53 and susceptibility to cell death in chemically-induced preneoplastic hepatocytes
(2003-11-20)
Induction of preneoplastic lesions, termed enzyme-altered foci (EAF), is considered to be an early step in the development of liver cancer. In view of the relatively homogenous properties of the majority of EAF, these ...
Local recurrence after breast conserving surgery in breast cancer
(2002-08-30)
The general aim of this thesis was to gain increased insight into the problem of local recurrences after breast conserving surgery for breast cancer. In a population-based cohort of 4,694 women with invasive breast cancer, ...