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On spinal mechanisms for reflex control in man : modulation of Ia-afferent excitation with changes in muscle length, activation level and fatigue
(2004-03-26)
To control muscle force, neural activation has to take alterations in
muscle mechanics into account. This thesis assesses modulations in
excitatory efficacy of Ia-afferents during muscle length changes at
different ...
Nasal and bronchial airway reactivity in allergic and non allergic airway inflammation
(2003-01-24)
In allergic or asthmatic airways disease, upper and lower airways show a uniform eosinophilic inflammation of the mucosa, and bronchial hyperreactivity is a common finding. To study the co- variation of mucosal reactivity ...
Neuromechanical control of the spine
(2003-05-23)
Control of the spine is complex. The spine is inherently unstable and dependent on the contribution of muscles. Yet there is considerable redundancy in the motor system with many muscles that act on the trunk.
This ...
Hereditary colorectal cancer : predisposition and prevention
(2004-01-23)
(VAS range 1-10).
There was a wide range of risk perception and 61% of the mutation
carriers reported their personal risk as being 40% or less. Increasing
age and a longer surveillance (increased number of colonoscopies) were
significantly...
Invasion promoting factors in endometriotic and endometrial tissue
(2004-05-14)
PA initiates pericellular proteolysis and cell migration, two processes required for tissue invasion. Two plasminogen activator inhibitors PAI-1 and PAI-2 regulate the plasminogen activating system. Plasmin, a highly potent protease, is able to degrade a broad...
Distribution and pathophysiological role of amyloid precursor protein and presenilin 1 : characterization in rats and in vitro studies on the pathogenic arctic mutation
(2002-11-01)
's disease cases. In a few families the disease is caused by pathogenic mutations located on three different genes encoding presenilin (PS) 1, PS2 and APP.
PS is an important component of the complex executing gamma-secretase processing of APP. A detailed...
New approaches for treatment of acute intermittent porphyria by enzyme substitution and gene therapy : evaluation in vitro and in vivo
(2004-05-07)
Acute intermittent porphyria (AIP) is a rare inborn metabolic error of
heme synthesis in which the activity of the third enzyme, porphobilinogen
deaminase (PBGD), is deficient. It is clinically characterized by ...
Sacroiliac pain-provocation testing in physiotherapy : time and force recording
(2004-08-27)
Introduction: Some of the tests used for examining pain arising from the
sacroiliac region are intended to provoke pain by using manually applied
forces. Previous reliability and validity studies of sacroiliac
pain-provocation ...
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
quinazolines, a type of heterocyclic compounds that is considered to be highly interesting as scaffolds for development of new drugs. When the acyl halide was a tertiary 2-haloacyl halide, the reaction instead gave 1,4-benzodiazepine-3-ones via rearrangement...
Studies on autoimmune diabetes in Latvians and other populations
(2001-10-09)
alleles. IDDM is positively associated with HLA DR3 and DR4 in Caucasians. From HLA-DQ molecules, DQ8 (DQA1*0301- DQB1*0302) is the most prevalent IDDM haplotype in Caucasians, followed by DQ2 (DQA1*0201-DQB1*0501). Taken together, DQ8, DQ2 or both account...