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Haemodynamic and ventilatory effects of laparoscopic surgery
(2004-01-23)
Background: It has been shown repeatedly that the establishment of pneumoperitoneum (PP) is associated with increased cardiac filling pressures, as well as increased blood pressure and systemic vascular resistance. Patients ...
Nestin regulation in the embryonic and adult CNS
(2001-11-09)
The developing mammalian central nervous system (CNS), i.e. the brain and spinal cord, is generated from neuroectodermal stem/progenitor cells lining the neural tube. The CNS stem/progenitor cells proliferate and migrate ...
Immunofluorescence studies on the cell cycle expression of cyclin A and cyclin E
(2004-04-07)
by phosphorylating a range of target proteins appropriate for the cell cycle phase in which the cyclin-CDK complex is active. Cyclin E-CDK2 is active in late G1 and phosphorylates proteins central to the progression through late G1 and entry into S-phase. Cyclin A...
Effect of pharmacological treatment of serotonergic function in depression
(2002-05-03)
parameters studied in this work were the active 5-HT uptake, the [3H]paroxetine binding to the 5-HT transporter and the [3H]LSD binding to 5-HT2A receptors. Since direct studies of the living human brain are associated with great methodological difficulties...
Bile in the oesophagus contributes to the development and complications of gastro-oesophageal reflux disease
(2002-05-10)
Objective: To clarify the relationship between duodenogastro- oesophageal reflux (DGOR) and gastro- oesophageal reflux disease (GORD) and its complications.
Methods: As persons who have had their gallbladders removed ...
Functional characterization of the alternative reading frame protein p14ARF
(2004-05-06)
in most malignant human tumors. Most intriguingly, both p53 and Rb proteins are in part regulated through the CDKN2A (INK4a/ARF) locus on human chromosome 9p21, a region frequently lost in tumors. This region encodes two structurally and functionally...
Circulating immune complexes in atherosclerotic vascular disease
(2001-08-31)
were evident within one
week in four young patients subjected to a 2-week elimination diet
followed by challenge with the alimentary antigen in question.
Elevated levels of CICs were present in patients with premature
peripheral atherosclerosis...
In silico prediction of CIS-regulatory elements
(2004-04-19)
As one of the most fundamental processes for all life forms, transcriptional regulation remains an intriguing and challenging subject for biomedical research. Experimental efforts towards understanding the regulation of ...
Characterization of human glutathione-dependent microsomal prostaglandin E synthase-1
(2003-08-29)
Prostaglandins (PGs) are lipid mediators, which act as local hormones. PGs are formed in most calls and are synthesized de novo from membrane-released arachidonic acid (AA) upon cell activation. Prostaglandin H synthase (PGHS) -1 or 2, also referred...
Clonidine in paediatric anaesthesia : pharmacokinetic and pharmacodynamic aspects
(2002-04-12)
Clonidine is a mixed alpha-2/alpha-1 adrenoceptor agonist. It reduces sympathetic and increases parasympathetic tone which results in a lowering of the baseline blood pressure and heart rate. Descending posjunctional noradrenergic antinociceptive...