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The uterine proteoglycan expression in pregnancy and labor
(2004-02-26)
Objective: Protracted labor is a common clinical problem causing maternal and fetal complications. It is the leading indication for caesarean sections throughout the world, and emphasizes our need to be able to control ...
Invasion promoting factors in endometriotic and endometrial tissue
(2004-05-14)
Endometriosis is a common gynaecologic disorder, affecting women of fertile age with pelvic pain and infertility, and is characterized by the presence of endometrial glands and stroma outside the uterine cavity. Retrograde ...
Smith-Lemli-Opitz syndrome : a disorder of cholesterol synthesis : diagnosis, treatment and pathogenetic aspects
(2002-09-06)
In 1993 it was first suggested that the Smith-Lemli-Opitz syndrome (SLOS), described almost 30 years earlier as a malformation syndrome, is caused by defective synthesis of cholesterol. Hypocholesterolaemia and accumulation ...
Leukocyte-endothelial interactions in arteries in vivo : a new concept in the study of physiology and disease in large blood vessels
(2001-11-23)
Pathophysiological events in large blood vessels contribute to immense
morbidity and mortality in our society. A major clinical problem is a
disease known as atherosclerosis. It involves a slow inflammatory
deposition ...
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
products were more or less complex 1,3-benzoxazinones, one of which required X-ray crystallography confirm its structure. During the work on preparation of N-substituted derivatives of Aa, necessary for synthesis of 1,4-benzodiazepine-3,5-diones...
The biological mechanisms in neutrophil and eosinophil adhesion and transmigration in vitro and theur relation to the inflammatory process in vivo
(2001-12-28)
in the quantitative up-regulation of CD11b/CD1 8
expression and increases the adhesion properties in primed, but not
resting, human eosinophils. We hypothesise that eotaxin and IL-5, but not
MP, act synergistically in these respects.
The adhesion and transmigration...
Functional and bioinformatical studies of the TGFb superfamily : identification and characterization of ALK7
(2001-11-02)
The transforming growth factor beta (TGFbeta) superfamily of polypeptide
growth factors encompasses more than 30 diverse mammalian members. They
are involved in most cellular processes, ranging from cell proliferation
and ...
Malignant mesothelioma : an experimental study with emphasis on proteoglycans in mesothelial cell growth and differentiation
(2002-04-17)
Malignant mesothelioma is a highly aggressive tumor with median survival ranging from 4 to 12 months and, despite intense therapeutical efforts, it is invariably fatal. Mesothelioma cells are unique in the sense that they ...
Nano-electrospray mass spectrometry for the analysis of neurosteroids and related molecules
(2003-03-10)
converted into their oximes which were detected as protonated molecules with 20 times higher sensitivity than the underivatised steroids. The detection limits for the oximes of 3-oxo-delta4, 20-oxo and 17-oxo steroids were 2.5, 5, and 25 pg/µL, respectively...
Local anesthesia for pain relief after surgery
(2001-11-16)
Postoperative pain is a common problem in spite of increased awareness
among patients and healthcare professionals. The prevailing practice is
still to administer opiates, which have a good painrelieving potential
but ...