Search
Now showing items 1-10 of 42
Microfluidic electrocapture technology in protein and peptide analysis
(2004-05-19)
After sequencing the genomes of several organisms, science in the postgenomic era now aims at a thorough study of the proteins present in a given tissue or organism. Since this task requires an enormous analytical effort, ...
On the role of cytochrome P450 3A4 in the metabolism of cholesterol and bile acids
(2003-12-19)
.
The physiological effects of elevated 4beta-hydroxycholesterol levels in humans is as yet unknown. However, previous studies have shown that 4beta-hydroxycholesterol is a relatively potent liver X receptor alpha (LXRalpha) agonist in cell-based transactivation...
Modulation of bile acid and cholesterol metabolism in health and disease
(2004-05-07)
An increased level of plasma cholesterol is associated with premature development of atherosclerosis. It is therefore important to understand the regulation of plasma cholesterol. Stimulation of hepatic bile acid synthesis ...
Molecular biology of Brouton's tyrosine kinase
(2003-11-14)
X-linked agammaglobulinemia (XLA) is caused by an arrest in the B lymphocyte differentiation. XLA patients lack mature B-cells and subsequently antibody production. The defective gene causing XLA is the BTK gene, which codes for the protein Bruton...
Diabetic osteopathy : a study in the rat
(2012-03-09)
The present study on non-obese Goto-Kakizaki (GK) rats with type-2 diabetes and neuropathy was an attempt to describe and define pertinent features of diabetic osteopathy. Altogether, the study included 33 GK rats aged 12 ...
Magnetic resonance imaging in chronic Achilles tendinopathy
(2004-03-05)
The main objective of this thesis was to evaluate and monitor the morphological response following treatment interventions in patients with chronic Achilles tendinopathy by using different MRI-techniques. For this purpose. ...
Studies on human polyomavirus infection in immunosuppressed patients with polyoma related tumors
(2001-09-21)
Polyomaviruses are potentially oncogenic viruses, found in humans, in other mammals and in birds all over the world. The polyomaviruses that have been observed in humans are BK virus (BKV) and JC virus (JCV) as well as the ...
The biological mechanisms in neutrophil and eosinophil adhesion and transmigration in vitro and theur relation to the inflammatory process in vivo
(2001-12-28)
In inflammatory reactions, eosinophils and neutrophils constitute the
major classes of granulocytes that emigrate from the bloodstream into the
tissues. The recruitment of inflammatory cells constitutes a multi-step
process ...
Birth centre care : reproduction and infant health
(2004-04-02)
This thesis has two general aims, to investigate factors affecting
women s decision to have a second baby and to study the effect of birth
centre care on infant outcome. The specific aims were to investigate 1)
whether ...
Endocrine and metabolic aspects of adult Prader Willi syndrome with special emphasis on the effect of growth hormone treatment
(2003-09-05)
Prader Willi Syndrome (PWS) is a complex genetic disorder characterized by muscular hypotonia, hyperphagia, obesity and behavioural problems. Partial growth hormone (GH) deficiency and hypogonadism are common. Results of ...