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Biophysical aspects of contact dermatitis and its prevention
(2004-03-05)
The skin, one of the largest organs of the body, is composed of three layers: the epidermis, dermis and subcutis. The outer most part of the epidermis i.e., the stratum corneum - serves as a protective barrier between the ...
In vitro models of xenograft rejection : studies on leukocyte-endothelial cell interactions
(2004-04-16)
Xenotransplantation is the transplantation of cells, tissues or organs
between different species and is a potential alternative to
allotransplantation because of the lack of human donors. The pig is
believed to be a ...
On characterisation and diagnosis of frontotemporal lobar degeneration syndromes : with special reference to the progressive aphasias
(2002-09-19)
patients showed 31% for the epsilon-4 allele and 69% for epsilon-3. This overrepresentation of allele epsilon-4 was similar to what had been found in AD. Tau protein CSF concentrations in SD were found to be moderately elevated compared to healthy controls...
Gene mapping of atopic dermatitis
(2001-11-14)
in 109 pedigrees forming 193 full-sib pairs and 9 half-sib pairs affected with atopic dermatitis. In total, five chromosome regions reaching the level for suggestive linkage (p<7.4x10-4) were identified. Four of these chromosome regions: 3q, 13q14, 15q14...
Studies of genetic and environmental influences on Parkinson’s disease
(2004-01-30)
Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. Little is known about the etiology of PD. Although several PD genes are known, these are thought to be involved in ...
Birth centre care : reproduction and infant health
(2004-04-02)
This thesis has two general aims, to investigate factors affecting
women s decision to have a second baby and to study the effect of birth
centre care on infant outcome. The specific aims were to investigate 1)
whether ...
Malignant mesothelioma : an experimental study with emphasis on proteoglycans in mesothelial cell growth and differentiation
(2002-04-17)
Malignant mesothelioma is a highly aggressive tumor with median survival ranging from 4 to 12 months and, despite intense therapeutical efforts, it is invariably fatal. Mesothelioma cells are unique in the sense that they ...
Effect of pharmacological treatment of serotonergic function in depression
(2002-05-03)
parameters studied in this work were the active 5-HT uptake, the [3H]paroxetine binding to the 5-HT transporter and the [3H]LSD binding to 5-HT2A receptors. Since direct studies of the living human brain are associated with great methodological difficulties...
Identification of the common eliminated region (CER1) by the microcell hybrid based 'elimination test'
(2001-11-27)
The aim of elimination test (Et) is to identify tumor antagonizing genes
from chromosome regions that are regularly deleted in microcell hybrid
(MCH) derived tumors through serial SCID mice passages. Et so far was
focused ...
Hepatitis C virus kinetics during antiviral treatment
(2004-03-05)
It is estimated that 170 million individuals have chronic hepatitis C virus (HCV) infection, whereof 20-30% will develop end stage liver disease within 20-30 years. Antiviral therapy can stop this deterioration and clear ...