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Gene regulation by nuclear hormone receptors in vivo
(2003-11-14)
The nuclear hormone receptor superfamily contains 49 different members, including those for thyroid hormone, TRα and TRβ. These receptors are ligand-modulated transcription factors that activate or repress gene activity. ...
Noradrenergic augmentation strategies in the pharmacological treatment of depression and schizophrenia : an experimental study
(2002-08-23)
inhibitors (SSRIs); an effect suggested to result from an antagonistic action of pindolol on somatodendritic 5-HT1A autoreceptors, reversing the acute, inhibitory, effect of SSRIs on serotonergic neuronal activity. However, upon systemic administration...
The role of periodontitis in cardiovascular disease
(2004-01-30)
Periodontitis and cardiovascular disease (CVD) are both common diseases affecting a large part of the society. Both diseases are considered to have a chronic inflammatory origin. During the last decades research has focused ...
Molecular basis for the anti-inflammatory properties of chlomethiazole
(2003-09-08)
Chlomethiazole (CMZ) exerts neuroprotective effects in animal models of stroke, and its clinical efficacy is currently evaluated in acute stroke patients. CMZ also protects the liver from alcohol- induced oxidative damage ...
Analyses of the expression and function of the aspartic protease napsin
(2004-04-02)
Two-dimensional gel electrophoresis (2 DE) is one of the powerful tools for the expression profiling of proteins. Using 2 DE, two polypeptides which are expressed exclusively in primary lung adenocarcinomas have been ...
Vestibular control of body orientation in lamprey
(2004-03-26)
Maintenance of body orientation (postural control) is a vital motor function of the brain. The general goal of this project was to understand the organization and operation of neuronal networks responsible for postural ...
Diabetic osteopathy : a study in the rat
(2012-03-09)
The present study on non-obese Goto-Kakizaki (GK) rats with type-2 diabetes and neuropathy was an attempt to describe and define pertinent features of diabetic osteopathy. Altogether, the study included 33 GK rats aged 12 ...
Angiostatic mechanisms of endogenous angiogenesis inhibitors
(2003-05-02)
. The structure of angiostatin consists of the first three/four kringle (K1-3/K1-4) domains of plasminogen. However, plasminogen contains five kringle structures and it has been shown that kringle 5 (K5) displays at least as potent inhibitory activity...
Morbidity in Ménières disease : aspects on quality of life and triggering factors
(2002-11-22)
Menieres disease is an inner ear disorder of unclear origin, characterized by severe attacks of simultaneously appearing fluctuant hearing loss, vertigo, tinnitus and a feeling of aural fullness. The disease has a well-known ...
Clinical application of QLF and DIAGNOdent : two new methods for quantification of dental caries
(2002-02-25)
General aim: The general objective of this thesis was to evaluate the clinical performance of two new methods for quantification of dental caries - the Quantitative Light-induced Fluorescence method (QLF) and KaVo ...