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Histochemical, biochemical and electrophysiological studies on dorsal root ganglion cultures : focusing on galanin, neuropeptide Y and glutamate
(2001-11-15)
work was to characterize dispersed DRG neurons in
culture, a putative model of axotomy, by (1) monitoring Gal and NPY and
their transcripts, (2) investigating the effects of neurotrophic factors
on peptide expression, Glu release and calcium levels and...
Regulation of dioxin receptor function by the Hsp90 chaperone complex
(2002-03-22)
In mammals the basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) family of transcription factors includes the dioxin receptor which is a ligand-dependent transcription factor which mediates biological effects of environmental ...
Quinine metabolism in man : emphasis on the 3-hydroxylation as a biomarker reaction for the activity of CYP3A4
(2002-04-05)
±8 %.
The role of CYP3A4 in the metabolism of quinine to 2'-quininone, (1OS)- and (1OR)-11-dihydroxydihydroquinine in vitro and the relative importance of these metabolites compared to 3-hydroxyquinine in the metabolism of quinine were studied in human liver...
Haemodynamic and ventilatory effects of laparoscopic surgery
(2004-01-23)
Background: It has been shown repeatedly that the establishment of pneumoperitoneum (PP) is associated with increased cardiac filling pressures, as well as increased blood pressure and systemic vascular resistance. Patients ...
Evaluation of the deoxyribonucleoside kinase of Drosophila melanogaster (Dm-dNK) as a suicide gene for treatment of solid tumors
(2002-05-16)
Nucleoside kinases from several species are investigated as "suicide genes" for treatment of malignant tumors. The transfer of the gene encoding herpes simplex virus type-1 thymidine kinase (HSV-1 TK) into malignant cells and subsequent treatment...
DARPP-32 in the striatum : multiple regulation and physiological role
(2001-08-24)
of the basal ganglia, and integrates inputs from
several neurotransmitters, e.g. glutamate from the cortex and dopamine
from the substantia nigra. When DARPP-32 is phosphorylated on the
threonyl residue, Thr34 it is a potent inhibitor of protein phosphatase-
1...
Digital intraoral radiography : determination of technical properties and application evaluations
(2002-05-03)
Digital registration of intraoral radiographs was introduced about 1990. One of the first systems on the market was the Sens-A-Ray (Regain Medical Systems AB, Sundsvall, Sweden). At the time of the introduction, it was ...
Elucidation of pro-apoptotic signaling induced by cisplatin
(2003-02-07)
to induce activation of Bak, and suggest a kinase fragment of MEKK1 (deltaMEKK1 ) as mediator of Bak activation, since activation was inhibited in cells expressing a kinase-inactive mutant of MEKK1 (dominant negative MEKK1, dnMEKK1). Involvement of delta...
Studies on human polyomavirus infection in immunosuppressed patients with polyoma related tumors
(2001-09-21)
HC. To investigate if primary BKV infection transmitted from donor to recipient during BMT could cause HC we investigated anti BKV serum titers in BMT recipients and their donors. We also sequenced the non coding control region (NCCR) and the VP1...
A concept for treatment of sports related knee injuries
(2004-04-02)
The aim of the present thesis was, to evaluate local anaesthesia as ananaesthetic technique when performing knee arthroscopies, from a clinicaland economical point of view, and to describe the total costs for surgeryof ...