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Pharmacogenetics of drug metabolizing enzymes with special emphasis on Ethiopians
(2003-02-14)
sequencing of CYP1A2 gene from 12 subjects revealed the presence of a novel intron 1 SNP, -730C>T. Genotyping and molecular haplotyping methods for the intron 1 SNPs were developed and 4 different haplotypes were identified: CYP1A2*1A (wt for all SNPs); CYP1A...
Specificity of neurotrophins in the nervous system : a genetic approach to determine receptor engagement by neurotrophins
(2004-01-02)
The classical neurotrophic factor hypothesis describes the neurotrophins as retrograde signalling factors supporting the survival of postmitotic neurons during the development. Knock-out mice for the neurotrophins and/or ...
DNA vaccines and bacterial DNA in immunity
(2002-11-22)
enhanced the protective effect of the DNA vaccine. Interestingly, in the absence of CD8 T cells, CD4 T cells induced by the p-hsp-60 DNA vaccine were involved in deteriorating the outcome of infection. This detrimental response was linked to a shift towards...
General practitioners' decision-making on drug treatment of hypercholesterolaemia
(2003-10-17)
Drug treatment of elevated cholesterol values may be indicated for individuals at high risk for cardiovascular disease and as a complement to lifestyle advice. Guidelines recommend a numerical risk calculation as the basis ...
Neuropeptide release in the rat dorsal horn in models of persistent pain : effects of opioids
(2002-05-03)
Nerve injury and tissue inflammation may lead to exaggerated responses to both noxious stimuli (hyperalgesia) and innocuous stimuli (allodynia). Altered release pattems of neurotransmitters in the dorsal hom of the spinal ...
Studies of genetic and environmental influences on Parkinson’s disease
(2004-01-30)
Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. Little is known about the etiology of PD. Although several PD genes are known, these are thought to be involved in ...
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
quinazolines, a type of heterocyclic compounds that is considered to be highly interesting as scaffolds for development of new drugs. When the acyl halide was a tertiary 2-haloacyl halide, the reaction instead gave 1,4-benzodiazepine-3-ones via rearrangement...
Studies on autoimmune diabetes in Latvians and other populations
(2001-10-09)
alleles. IDDM is positively associated with HLA DR3 and DR4 in Caucasians. From HLA-DQ molecules, DQ8 (DQA1*0301- DQB1*0302) is the most prevalent IDDM haplotype in Caucasians, followed by DQ2 (DQA1*0201-DQB1*0501). Taken together, DQ8, DQ2 or both account...
Magnetic resonance imaging in chronic Achilles tendinopathy
(2004-03-05)
The main objective of this thesis was to evaluate and monitor the morphological response following treatment interventions in patients with chronic Achilles tendinopathy by using different MRI-techniques. For this purpose. ...
Drug treatment in children with focus on off-label drug use
(2010-08-06)
There is a lack of paediatric documentation concerning efficacy and
safety of many drugs, which contribute to drug use outside the terms of the product license (off-label). In the present thesis, four studies (I-IV), using ...