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Neuronal nicotinic receptor subtypes in normal ageing, Alzheimer's disease and schizophrenia : influences of neuropathological mechanisms as studied in human autopsy brain and transgenic mice
(2002-02-08)
in cortical regions of sporadic AD cases versus those in subjects with familial Swedish APP 670/671 encoded mutation AD (FAD APP 670/671) showed that mutation carriers had similar deficits in nAChRs. This indicated that pronounced disturbances in APP...
Hemostasis in middle-aged women with coronary heart disease
(2004-08-20)
were included in the study. The mean age±SD were 56±7 years in both patients and controls. Plasma levels of fibrinogen, coagulation factor VII (FVII), von Willebrand factor antigen (vWFag) and plasminogen activator inhibitor1 activity (PAI-1), and serum...
Matrix degrading proteases in vascular disease
(2002-11-22)
polymorphisms within the promoter regions of MMP-7 and MMP-12. In the MMP-7 promoter we found two polymorphisms located at -181 with an A to G substitution and the other one at -153 with a C to T substitution. Both of the MMP-7 polymorphisms were associated...
Tuberculosis : diagnosis and drug susceptibility testing where resources are scarce
(2004-01-09)
system called BacT/ALERT 3D
for primary detection of M. tuberculosis in clinical samples and for drug
susceptibility testing.
Results: We found that the bleach method could improve sensitivity with 3
7 %, Arith unchanged specificity, in Honduras...
Risky alcohol consumption in the workplace : the feasibility of early detection and brief intervention as a part of routine health examinations
(2002-03-27)
There are a number of reasons why workplaces should focus on problems related to alcohol use and misuse. These include the associated risk of greater ill-health, accidents leading to injury, absenteeism, and negative effects ...
Inborn errors in the metabolism of glutathione
(2002-11-15)
Glutathione (GSH) is a tripeptide present in all mammalian cells. It takes part in several fundamental biological functions, including handling of reactive oxygen species (ROS), detoxification of xenobiotics and carcinogens, ...
Isolation and characterization of regulatory peptides and bioactive compounds
(2004-04-28)
Isolation of peptides and other bioactive compounds is an important and often necessary step to get the total information about their structures. This is demonstrated by a number of different characterizations in this ...
Maternal deprivation and mood stabilizing drugs : effects on rat brain NPY
(2002-10-04)
Experiences of early adverse life events are more frequent among adult depressed patients than healthy subjects. Studies with non-human primates and rats show that maternal deprivation leads to changes in hypothalamic-pituitary ...
Physical activity in men and relation to prostate cancer
(2004-05-07)
hundred eleven men in central Sweden, aged 44-78, completed the questionnaire and one or two 7-day activity records used as the reference method. Spearman correlation coefficient was 0.56 between total daily activity score estimated from the first...
Autoimmune markers in autoimmune diabetes
(2003-12-19)
Type 1 diabetes mellitus (T1DM) is an autoimmune disease, characterized by autoimmune mediated loss of insulin secreting Beta-cells. The disease is associated with certain HLA class 11 haplotypes. HLA DR3-DQ2 and DR4-DQ8 ...