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Immunogenetic markers in immune mediated diseases
(2003-11-21)
connective tissue disease (MCTD) and type I diabetes mellitus (T1 DM).
HLA class II genes are located on the short arm of chromosome 6 and are known to be important for pathogenesis of immune-mediated diseases due to the function of the molecules...
Nephrin cellular trafficking and intracellular interactions
(2004-04-23)
to interact with Neph1, another interacting partner of nephrin in the slit diaphragm protein complex. Furthermore, tyrosine phosphorylation of the rescued mutants was rapidly induced by clustering with anti-nephrin antibodies as wild type, implying...
Long-wave ultraviolet radiation (UVA1) and visible light : therapeutic and adverse effects in human skin
(2001-09-05)
We studied the effects of repetitive low-dose UVA1 radiation and visible
light in normal sunshielded skin, using immunohistochemical staining for
p53, p21WAF-1, bcl-2, Ki67 and cyclin A. An increased expression of Ki67
after UVA1 and visible light...
Some determinants of sick leave for respiratory disease : occupation, asthma, obesity, smoking and rehabilitation
(2002-09-20)
The cost to society of sick leave and disability pensions is currently
the most urgent economic problem in Sweden. The availability of a large
sick-listing database, Collective Group Health Insurance, AGS (in
Swedish: ...
Pharmacogenetics of human cytochrome P450 3A (CYP3A) enzymes
(2003-10-24)
that could contribute to the variable expression seen in CYP3A expression and metabolism.
The proximal promoter of the CYP3A4 gene in a pool of human liver samples were sequenced in search of genetic variations. CYP3A4*1B was found in three of 39 livers...
Development of a new PNA analogue as a potential antisense drug and tool for life-science studies
(2004-05-13)
The work described in this thesis focuses on applying synthetic organic chemistry methods (supported by modem synthesizers and analytical techniques) for the preparation of peptides and modified nucleic acids in order to ...
Appetitive and consummatory ingestive behavior : role of taste, dopamine and NPY
(2001-11-23)
The present thesis has examined the role of taste, dopamine and
neuropeptide Y (NPY) in the regulation of the two phases of ingestive
behavior: appetitive (approaching and handling of food) and consummatory
ingestive ...
Hepatitis C in chronic kidney disease and kidney transplantation : with special reference to epidemiology and treatment
(2003-10-31)
Hepatitis C (HCV) is a clinical problem in infected kidney transplant patients but is also a cause of renal disease and vasculitis. Standard therapy for HCV is a combination of interferon and ribavirin. Renal patients have ...
The transcription machinery in schizosaccharomyces pombe and its regulation
(2004-04-28)
transcription. We purified S. pombe general initiation factors TFIIB, TFIIF, TFIIE, and TFIIH to near homogeneity. These factors enabled highly purified RNA polymerase II to initiate transcription from the S. pombe alcohol dehydrogenase promoter (adh1p) when...
Concepts in DNA immunization overcoming viral diversity and enhancing plasmid immunogenicity
(2004-05-07)
immunogen is of importance for efficient induction of immunity. Further, antibody responses to a DNA immunogen can be substantially enhanced if the genetic immunogen is coupled to a carrier, in our case the polyomavirus VP1 capsid. In combination...