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Pregnancy related risk factors for breast cancer
(2003-12-19)
Pregnancies offer a life-long reduction in breast cancer risk. It has
repeatedly been shown that both number of pregnancies and age at first
birth affect the future breast cancer risk. The mechanisms for this
protection ...
Expression and activity of Myc network proteins during cell cycle progression and differentiation
(2004-03-05)
by Mot, is transiently inhibited upon entry of quiescent fibroblasts into the cell cycle. Mnt directly binds and recruits mSin3 to the promoter of a Myc target gene, cyclinD2, in G0 but not in the G1 phase. We suggest that transcriptional repression...
Studies of genetic and environmental influences on Parkinson’s disease
(2004-01-30)
Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. Little is known about the etiology of PD. Although several PD genes are known, these are thought to be involved in ...
Carbon dioxide de-airing in cardiac surgery
(2004-01-09)
.65% remaining air), while the 2.5mm and 6.35mm open-ended tube were much less efficient with >=82% and >19.5% remaining air, respectively, at 2.5-10 I/min C02 flows (p<0.001). When using the gas-diffuser, an open pleural cavity prolonged the time needed...
Endocrine and metabolic aspects of adult Prader Willi syndrome with special emphasis on the effect of growth hormone treatment
(2003-09-05)
Prader Willi Syndrome (PWS) is a complex genetic disorder characterized by muscular hypotonia, hyperphagia, obesity and behavioural problems. Partial growth hormone (GH) deficiency and hypogonadism are common. Results of ...
Mild cognitive impairment neuroimaging markers for early diagnosis of dementia
(2003-09-12)
This thesis concerns the investigation of mild cognitive impairment (MCI) and Alzheimer's disease (AD) using single photon emission computed tomography (SPECT) and quantitative electroencepholography (qEEG).
In study ...
Lower limb ischemia in women
(2004-02-27)
. Women were older than men (71 years vs 66, p<0.001). The localisation of lesions treated for chronic LLI was similarly distributed between women and men. Women had poorer survival than men. In a Cox regression model, increasing age, later calendar years...
Increased glucocorticoid sensitivity in pancreatic beta-cells : effects on glucose metabolism and insulin release
(2003-05-23)
Type 2 diabetes mellitus (T2DM) is characterized by three pathological alterations: (1) insulin resistance in peripheral tissues, (2) increased hepatic glucose production and (3) impaired insulin secretion from the pancreatic ...
Radiologic diagnosis of appendicitis in children
(2004-04-23)
Suspected appendicitis is the most common cause of emergency abdominal surgery in children. Because of the often atypical clinical findings, the diagnosis of appendicitis is difficult and may be delayed. Perforation has ...
Intestinal functions in animals : an experimental study on horses, pigs, cows and fish
(2001-11-07)
Animals and humans live in symbiosis with an active gastrointestinal
ecosystem. The balance of the system is maintained by the main actors,
the macroorganism, the microflora and the environment, in concert.
Microflora ...