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Langerhans cell histiocytosis : detection, monitoring and pathophysiology
(2002-04-26)
Langerhans cell histiocytosis (LCH) is a rare disease that may occur at any age but mainly affects children. Clonally expanded Langerhans cells together with lymphocytes, eosinophils and macrophages form destructive ...
Pharmacogenetics of drug metabolizing enzymes with special emphasis on Ethiopians
(2003-02-14)
effect on CYP2D6 and have contributed to dietary related selection for CYP2D6 duplication in Ethiopians. We screened for new SNPs in the CYP1B1 gene and detected 3 novel SNPs one of which (4360C>G in exon 3) was present at a frequency of 7 %, and causes...
Hepatitis C virus kinetics during antiviral treatment
(2004-03-05)
It is estimated that 170 million individuals have chronic hepatitis C virus (HCV) infection, whereof 20-30% will develop end stage liver disease within 20-30 years. Antiviral therapy can stop this deterioration and clear ...
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
quinazolines, a type of heterocyclic compounds that is considered to be highly interesting as scaffolds for development of new drugs. When the acyl halide was a tertiary 2-haloacyl halide, the reaction instead gave 1,4-benzodiazepine-3-ones via rearrangement...
Identification of the common eliminated region (CER1) by the microcell hybrid based 'elimination test'
(2001-11-27)
The aim of elimination test (Et) is to identify tumor antagonizing genes
from chromosome regions that are regularly deleted in microcell hybrid
(MCH) derived tumors through serial SCID mice passages. Et so far was
focused ...
Temporomandibular joint involvement by systemic inflammatory disease with reference to pain modulation and joint tissue destruction
(2003-11-07)
study was to investigate if the 5-HT3 antagonist granisetron reduces TMJ pain. An intra-articular injection of granisetron (1mg) given in a randomized double-blind manner reduced the resting pain in the TMJ according to a visual analogue scale after 10...
Studies on autoimmune diabetes in Latvians and other populations
(2001-10-09)
alleles. IDDM is positively associated with HLA DR3 and DR4 in Caucasians. From HLA-DQ molecules, DQ8 (DQA1*0301- DQB1*0302) is the most prevalent IDDM haplotype in Caucasians, followed by DQ2 (DQA1*0201-DQB1*0501). Taken together, DQ8, DQ2 or both account...
Morphological and molecular changes in developing guinea pig osteoarthritis
(2003-01-31)
Osteoarthritis (OA) - an unspecific term for late joint destruction-is one of the most common causes of pain and disability in elderly. OA is characterized by destruction of articular cartilage and insufficient tissue ...
Lower limb ischemia in women
(2004-02-27)
Arteriosclerosis is a general disease affecting different parts of the arterial system. In coronary heart disease (CHD) women have different risk factors, symptoms, indication for treatment, interpretation of diagnostic ...
Drug treatment in children with focus on off-label drug use
(2010-08-06)
There is a lack of paediatric documentation concerning efficacy and
safety of many drugs, which contribute to drug use outside the terms of the product license (off-label). In the present thesis, four studies (I-IV), using ...