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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Teenage parenthood : paternal characteristics and child health outcomes
(2004-08-13)
fathers were present on postnatal wards in Stockholm between May 1997 and April 1998. Papers III and IV are national cohort studies based on Swedish national registers. The study population in Paper III comprised all 800.190 children born in Sweden during...
Identification, cloning and characterization of the p53 induced gene human Wig-1
(2004-11-26)
is induced following activation of wild type p53. Northern
blotting detected low levels of wig-1 mRNA in normal human tissues.
Fluorescence in situ hybridization mapped human wig-1 to chromosome
3q26.3-27. FLAG-tagged human wig-1 localizes to the nucleus...
Studies on growth hormone induced female-characteristic gene transcription in rat liver
(2005-05-06)
' and a 2.3kb a1bg promoter construct was used in in vivo transfection assays. Sexually dimorphic reporter expression was displayed and the transactivation was dependent on a continuous exposure of the rat liver to GH. Truncation of the 2.3kb a1bg...
Improving medical abortion : using mifepristone in combination with a prostaglandin analogue
(2005-09-16)
Background: Induced abortion is still a major health problem in the world and the most frequently performed intervention in Obstetrics and Gynaecology with an estimated total of 46 millions worldwide each year. Medical ...
Prediction of function shift in protein families
(2006-08-14)
With the availability of a large number of complete genome sequences, it has become essential to annotate the protein sequences derived from them as precisely as possible. Even though presently available computational ...
Genetic association analysis of overlapping biological pathways in cardiovascular and Alzheimer disease
(2006-05-26)
, making ACE an intriguing biological candidate for both AD and cardiovascular disease. Significant effects for markers in the promoter and 3'-regions were found upon AD risk and disease age-of-onset, consistent with the presence of allelic heterogeneity...
Novel insulin-like growth factor-binding protein proteases : detection and characterization
(2006-10-07)
the availability of IGFs (IGF-I and IGF-II) to their receptors. In the circulation IGFs and IGFBP-3 or IGFBP-5 can bind an acid-labile subunit (ALS) to form a high molecular mass complex, which constitutes a circulating reservoir of IGFs. Post...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Female and male infertility in Nigeria : studies on the epidemiology of infertility in Nigeria with special reference to the role of genital tract infections and sexual and reproductive risk factors
(2005-05-05)
Background: Infertility is a major public health problem in Nigeria,
contributing to inappropriate contraceptive behavior and poor sexual and
reproductive health of women. To date, there is a paucity of scientific
information ...