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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Prediction of function shift in protein families
(2006-08-14)
With the availability of a large number of complete genome sequences, it has become essential to annotate the protein sequences derived from them as precisely as possible. Even though presently available computational ...
Atomic force microscopic studies of inner ear structure and mechanics
(2004-09-10)
evaluated local elastic properties at different positions on the OHC membrane.
(5) AFM was used to investigate the mechanical responses of isolated OHCs to indentation by the AFM tip. Indentation curves showed a break at the contact point, a feature...
Prenatal diagnosis in routine antenatal care : a randomised controlled trial
(2005-11-04)
-week group (0.5/1,000 vs. 0.8/1,000, n.s.). For every case of DS prenatally detected, 38 and 85 amniocenteses were performed. Excluding testing for reasons other than those defined in the study protocol, the corresponding figures were 16 and 89...
Aspects on the etiology of esophageal and gastric cancer
(2004-11-12)
completeness of the Cancer Register of 98.3%, while the site-specific accuracy was only 63% for esophageal adenocarcinoma, 74% for gastric cardia adenocarcinoma, and 91% for esophageal squamous-cell carcinoma. The increasing incidence rate of esophageal...
Synovial metabolism after knee joint arthroscopy : a microdialysis study
(2006-03-03)
Postoperative pain and swelling of the knee is a general finding after arthroscopy. In order to optimize and individualize the treatment it is of great importance to increase basic knowledge of perioperative local biochemical ...
Study of serotonin, innervation and sensory neuropeptides in allergic contact dermatitis
(2005-08-17)
In a murine model of contact allergy, 24 h after challenge with antigen, increased axonal growth using an antibody to growth-associated protein-43 (GAP-43) was seen in the epidermis and dermis of eczematous skin. Protein gene product 9.5 (PGP 9.5...
Formyl-coenzyme : a transferase, structure and enzymatic mechanism
(2004-08-20)
Background: Formyl-CoA transferase (Frc) is the first enzyme in a two
enzyme pathway responsible for oxalate degradation in Oxalobacter
formigenes. This bacterium is a constitutive part of human intestinal
flora. Its ...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
PET studies of the serotonin transporter in the human brain
(2006-10-27)
The serotonin (5-HT) system attracts considerable attention in research on the pathophysiology and drug treatment of neuropsychiatric disorders. The brain imaging technique Positron Emission Tomography (PET) allows for examination...