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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Cataract from ultraviolet radiation in the mouse
(2005-11-25)
of 5 kJ/m2 UVR-B 300 nm induces light scattering in the mouse lens. In vivo exposure to UVR-B induces anterior subcapsular cataract and occasionally cortical and nuclear cataract 1-8 days after exposure to UVR. Light scattering transiently peaks 48...
Biological aspects of synovial fluid mediated aseptic prosthesis loosening
(2005-08-26)
Aseptic prosthesis loosening is the most common reason for late failure of total hip arthroplasties. Resorption of the peri-prosthetic bone, resulting in a loose prosthesis is characteristic for aseptic loosening. The ...
Urothelial cell culturing : in vitro and in vivo studies in reconstructive pediatric surgery
(2004-11-26)
in vitro cultured
urothelial cells were seeded on a carrier material of acellular dermis
for transplantation to the neourethra. Six patients with severe
hypospadias have been treated with this new technique. All patients show
favorable results 2-5 years...
Cellular responses to respiratory chain dysfunction
(2005-10-07)
reduced in RC deficient hearts and smaller and faster Ca2+ transients and reduced Ca2+ storage capacity of the sarcoplasmic reticulum was found in isolated Tfam knockout cardiomyocytes.
Interestingly, beta-adrenergic stimulation induced an irregular Ca2...
Regulatory mechanisms and plasticity of nicotinic receptors in transgenic mice overexpressing human beta-amyloid (APPswe) and acetylcholinesterase : implications for Alzheimer’s disease
(2005-01-07)
showed that the alpha4 and the alpha7 nAChR subtypes were upregulated following treatment with galantamine in the hippocampus (alpha4), cortex (alpha7) and thalamus (alpha7) in the control mice. The M1 and M2 mAChRs were found to be nonselectively...
Hormonal mechanisms of menstrual disturbances, metabolic disorders and effects of oral contraceptives in female athletes
(2004-11-12)
Background: During the last decades the number of women participating in sports has increased dramatically. Although exercise has beneficial health effects for most of these women, we now realize that strenuous exercise ...
Aldehyde toxicity in human oral epithelium
(2004-11-19)
demonstrated distinct toxicity profiles of formaldehyde, acetaldehyde and methylglyoxal in NOK and the SV40 T antigen immortalized human oral keratinocyte line SVpgC2a. Endogenous and induced acetaldehyde and methylglyoxal DNA adducts was demonstrated by 32P...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Genetic association analysis of overlapping biological pathways in cardiovascular and Alzheimer disease
(2006-05-26)
), Presenilin 1 (PSEN1), and Presenilin 2 (PSEN2) have been described to cause the early-onset familial form of AD. However, the discovery of genes involved in sporadic late-onset AD has proven to be more difficult. Apolipoprotein-E (APOE) which mediates lipid...