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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Identification of new proteins and biological processes in the apicomplexan Toxoplasma gondii
(2006-11-20)
strong binding and specificity for heparin, making them candidate receptors for this ligand.
Proteomics analysis of surface-associated heparin-binding proteins led to the discovery of two new internal membrane complex-associated proteins, IMC6 and IMC7...
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) disrupts vitamin A homeostasis in rodents : quantitative and mechanistic studies to support risk assessment
(2005-11-25)
and hamsters. In
terms of sensitivity compared to CYP1A induction (measured as EROD
activity), ED50 values were 0.2, 6.6, 6.5 and 13.7 µg/kg bw, in guinea
pigs, rats, mice and hamsters respectively. In Long-Evans rats, long-term
low-dose TCDD exposure disrupted...
Viral zoonoses in Estonia : hantaviruses and tick-borne encephalitis virus : identification, prevalence, serological and genetic relationships
(2006-02-15)
, suggested that SAAV and DOBV represent distinct hantaviruses.
Two rodent species, C. glareolus and A. agrarius, were found positive for hantavirus antigen at rates of 13,7% and 4,5% of the investigated rodents, respectively. Analysis of viral sequences...
Intake of fruit and vegetables in European children and their mothers, folate intake in Swedish children and health indicators : overweight, plasma homocysteine levels and school performance
(2005-11-18)
.
Height and weight of the children from parent questionnaires were
analyzed in relation to fruit and vegetable intake. Overweight and
obesity rates were assessed using international cut-off levels. A 24-hour
recall was used to assess folate intake of 1,137...
Motivating clinical treatment of obesity : methods, education, supervision and outcome
(2004-11-05)
Obesity has become an important health problem worldwide. It increases
the medical risks and affects daily living. Environmental factors such as
diet and sedentary lifestyle are likely to be the cause. In Sweden, the
number ...
Evaluation of the infrared reflection method for saccadic eye movement velocity analysis
(2005-12-29)
Saccades are rapid eye movements that change the orientation of the eyes onto objects of interest. In an every day situation saccadic eye movements are used for e.g. reading, scanning objects and enviromnents.
The ...
Mucosal immune responses in HIV-1 exposed uninfected individuals
(2006-10-20)
The development of HIV vaccines and immunotherapeutics remains hampered by our lack of understanding correlates of immune protection to infection and disease. The major (perhaps only) piece of evidence indicating that ...
Synthesis of indole and oxindole derivates incorporating pyrrolidino, pyrrolo or imidazolo moieties
(2004-11-26)
-chloroacrylonitrile yielded, after expulsion of HCN by refluxing in ethanol, 1-benzyl-4,5,6,7-tetrahydroindole. Formylation and benzylimine formation followed by treatment with TosMIC furnished the desired 2-imidazolyltetrahydroindole....
Studies on the mechanism of regulation of bile acid synthesis in humans with some aspects on genetic factors
(2005-10-28)
In the present investigation we studied human bile acid synthesis and its regulation both in vivo and in vitro and also evaluated a possible influence of polymorphisms in the CYP7A1 and CYP8B1 genes on bile acid synthesis in vivo. The following...