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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Prevention and treatment of hepatitis B virus infection
(2005-05-06)
) boosters in non-responders were retrospectively analysed. Seroprotection was achieved in 1,517/1,840 (82.5%) vaccinees. Among non-responders, two-thirds had no detectable antibodies and one-third had levels of 1-9 IU/L (hypo-responders). In the group...
Neurogenesis, neural stem cells and nitric oxide in neuroinflammation
(2005-09-23)
We investigated whether nitric oxide (NO) is produced in MS patients, determining the concentrations of its oxidation products (NOx) in CSF. The total levels of NOx in CSF were significantly increased in all MS groups as ...
Hormones and breast cancer : aspects on receptor expression and metabolism
(2006-02-17)
Breast cancer is the most common malignancy among women in the western world. Sex steroid hormones are implied as risk factors but endocrine regimens are also used in the therapy of breast cancer. Current knowledge about ...
Synthetic studies of marine indole alkaloids and related systems
(2005-11-25)
and 8,9dihydrobarettin, isolated from the marine sponge Geodia baretti. The synthesis of barettin and 8,9dihydrobarettin was performed in this work, involving a highly functionalised arginine derivative. This arginine derivative was used in a peptide...
Genetic association analysis of overlapping biological pathways in cardiovascular and Alzheimer disease
(2006-05-26)
lies in proximity to an AD linkage peak on chromosome 9q, making ABCA1 both a biological and positional candidate. In four independent European populations, significant differences in genotype frequencies were found between cases and controls indicated...
Prediction of function shift in protein families
(2006-08-14)
With the availability of a large number of complete genome sequences, it has become essential to annotate the protein sequences derived from them as precisely as possible. Even though presently available computational ...
The role of incretin peptides and ghrelin in upper gut motility and metabolic control
(2006-11-24)
Metabolic control is essential for the individual and is strictly regulated via a wide range of factors. One important mechanism in maintaining an adequate blood sugar level is the regulation of insulin release and gastric ...
Cellular and molecular mechanisms in abdominal aortic aneurysm growth and rapture
(2005-11-11)
-degrading proteases in the AAA wall. Gene arrays and quantitative real-time PCR showed that matrix metalloproteinase (MMP)-1, -7, -9 and -12 mRNA expressions were upregulated in the thrombus-free wall compared with the thrombus-covered wall. Immunohistochemistry...
Viridans group streptococci septicaemia and endocarditis : molecular diagnostics, antibiotic susceptibility and cinical aspects
(2005-04-27)
Viridans group streptococci (VGS) are inhabitants in the oral cavity and in the gastrointestinal tract. They cause severe infections, they are responsible for up to 39 % of the cases of septicaemia in neutropenic patients ...