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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Cryo-electron tomography of individual protein molecules
(2005-08-29)
Averaging methods of determining structure, such as X-ray diffraction, do not preserve information about the flexibility of molecules. Cryo-electron tomography allows us to reconstruct individual hydrated objects. The ...
Testosterone treatment in women : aspects on sexuality, well-being and metabolism
(2004-11-05)
The expected postmenopausal lifetime of women in the western world is
about 30 years. Hormones, such as estrogen and progestogen, may affect
the quality of postmenopausal life and have been well studied. Androgens
act ...
Opioids and regulation of breathing
(2004-10-29)
A most important challenge even in modern medicine is effective treatment of pain. Respiratory depression is the most feared side effect of analgesic treatment in the clinical situation. The serious effect of opioid induced ...
Studies of sterol 12alpha-hydroxylase (CYP8B1) : distribution and role for cholesterol homeostasis and gallstone formation
(2006-05-19)
, with an increasing gradient from the portal areas towards the central veins. Such a pattern was also observed for the histochemical distribution of mouse Cyp7a1.
Cyp8b1-/- mice were found to accumulate much less hepatic cholesterol than Cyp8b1+/+ mice when fed...
The epidemiology of low back pain in the general population and after motor vehicle collisions : population-based investigations
(2004-11-23)
prevalence of LBP in Saskatchewan adults was 28.4%
and 84. 1 % respectively. The six-month prevalence of mild, intense and
disabling LBP was 48.8%, 12.3 % and 10.7% respectively. There was little
variation in prevalence across age groups, but women...
Impaired glucose tolerance in ischemic heart disease
(2005-11-18)
undiagnosed until they have developed overt
diabetes or cardiovascular complications.
Patients and methods: A total 123 patients, aged 31-80 years with a
previous acute myocardial infarction (MI) but without a known DM were
examined. A standard oral glucose...
Early oncogenic events and defective apoptosis in prostate cancer
(2005-03-18)
Prostate cancer is one of the most common malignancies in males in the Western world. Although the mechanisms are unclear, it is generally believed that the accumulation of genetic alterations leads to the tumor formation. ...
On the influence of glia on neurite outgrowth from dopamine neurons in the nigrostriatal system
(2004-11-26)
Interactions between glial cells and neurons are important during fetal development, in the maintenance of the normal functions in tile central nervous system (CNS), arid in response to injuries or diseases. Some of die ...
Tumor lipid status and the responses to therapy in neuroblastoma : with emphasis on treatment monitoring by proton magnetic resonance spectroscopy
(2004-11-18)
In this thesis, the aberrant lipid and phospholipid metabolism of
neuroblastoma was exploited for tumor monitoring and as target of
experimental therapy. Neuroblastoma is the most common and deadly solid
tumor of ...