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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Immunodominant proteins in Giardia lamblia
(2004-11-19)
during a waterborne outbreak
in Sweden. Several of the identified proteins (i. e. alpha-1-, alpha-2-,
alpha-7.1-giardin, OCT and ADI) were produced in recombinant form, mixed
and used successfully as a diagnostic tool to screen sera from infected
patients...
Influence of exposure patterns and oxidation in UVR-induced cataract
(2005-04-29)
days and 30 days). In the second study (reciprocity), each rat was exposed to 8 kJ/m2 UVR for a different length of time (5, 7.5, 11, 15, 30, 60, and 120 minutes). In the third study (vitamin E and cataract) rats were fed vitamin E...
Exercise and angiogenic growth factors in human skeletal muscle
(2005-05-20)
angiogenesis in adult animal tissue. In situations with increased expression of Ang-2 and high availability of VEGF-A a favourable impact exists on the angiogenic process through Ang-2 induced endothelial destabilization, which facilitates the effects of VEGF...
Interactions between mouse CNS cells : microglia and neural precursor cells
(2004-11-05)
The mammalian central nervous system (CNS) contains a variety of cells,
all specialized to perform different functions. Most numerous are the
three types of glia cells, whose basic role is to support the signaling
units ...
The human antimicrobial protein hCAP18/LL37 in wound healing and cell proliferation
(2005-08-26)
Epithelia constitute the principal barriers separating the host and the potentially injurious environment, and defence of this interface is therefore essential. Antimicrobial peptides are key effector molecules of the ...
Functional studies on the interaction of immunoglobulins with HIV-2 envelope
(2005-09-16)
was cloned, and two constructs of HIV-2 gp125 were designed as previously described for HIV-1 gp120, where in the gp125deltaV1V2 construct the V1/V2 region was excluded. These gp125 constructs were expressed in CHOlec cells as glycosylated proteins...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Synthetic studies of marine indole alkaloids and related systems
(2005-11-25)
-carboxaldehyde and 1,4-diacetyl-2,5-piperazinedione ill the presence of caesium carbonate. Several analogues of dipodazine, together with a few barettin analogues have been prepared and tested for activity ill antifouling assays, results and relevance of which...
Synthesis of indole and oxindole derivates incorporating pyrrolidino, pyrrolo or imidazolo moieties
(2004-11-26)
The focus of this thesis is on the synthesis of oxindole- and indole-derivatives incorporating pyrrolidins, pyrroles or imidazoles moieties.
Pyrrolidino-2-spiro-3'-oxindole derivatives have been prepared in high ...