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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Effect of body posture on regional ventilation and perfusion at normal and increased gravity
(2006-10-20)
The prone position is increasingly used to improve arterial oxygenation in intensive care patients with severe acute respiratory failure. This beneficial response is well documented but our understanding of the responsible ...
A role of sympathetic nervous system in immunomodulation of early experimental African trypanosomiasis
(2004-11-25)
African trypanosomiasis or sleeping sickness is a protozoan disease prevalent in Sub-saharan Africa. It is caused by the genus Trypanosoma and occurs in humans and animals and is transmitted by infected tsetse flies. ...
Diet and renal cell carcinoma
(2005-01-14)
was estimated by comparing to the patterns based on4x7-day dietary records in 129 women from the SMC cohort; reproducibility was estimated in 212 women by comparing patterns from two FFQs filled in 1 year apart (paper III). In analyses of the association between...
Clinical, immunological and olfactory aspects of sinusitis and nasal polyposis : with special reference to patients with cystic fibrosis
(2004-11-26)
The otorhinolaryngological approach to the problem concerning
rhinosinusitis and nasal polyposis in the recessive genetic disorder of
cystic fibrosis (CF) has been developed based on data from international
studies. ...
Synthetic studies of marine indole alkaloids and related systems
(2005-11-25)
This thesis is mainly focussed oil the synthesis of marine indole alkaloids and related systems, many of which display interesting biological activities.
In the first part of this thesis we could establish and confirm ...
Genetic association analysis of overlapping biological pathways in cardiovascular and Alzheimer disease
(2006-05-26)
To gain insight into the importance of the genome for diseases, sequencing and genotyping efforts aim to identify the consequences of genetic variation on both a functional and population level. The task involves the ...
The study of sensory cilia development in Caenorhabditis elegans
(2008-01-04)
Cilia and flagella are widespread eukaryotic subcellular components
that are conserved from green algae to mammals. In different organisms
they function in cell motility, movement of extracellular fluids and
sensory ...
Synthesis of indole and oxindole derivates incorporating pyrrolidino, pyrrolo or imidazolo moieties
(2004-11-26)
The focus of this thesis is on the synthesis of oxindole- and indole-derivatives incorporating pyrrolidins, pyrroles or imidazoles moieties.
Pyrrolidino-2-spiro-3'-oxindole derivatives have been prepared in high ...
Platelets and eosinophils in lung tissue remodelling
(2006-08-25)
Tissue injury and inflammation followed by effective repair restores normal function, but defective repair with associated tissue remodelling and fibrosis can lead to loss of organ function. Thus, interactions between ...