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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Sleep and cardiovascular health in women : the Stockholm female coronary risk study
(2004-11-12)
over a longer time period has been studied.
Aims: 1) To examine the effect of poor sleep quality on prognosis of CHD
and wether this association can be explained by depression. 2) To examine
the association between the metabolic syndrome, snoring...
Kostmann syndrome : a clinical and pathophysiological study
(2004-10-15)
-apoptotic protein Bcl-2, and both these findings normalized after the initiation of G-CSF treatment. We also found increased apoptosis in myeloid progenitor cells; especially CD33+ cells were prone to apoptosis. Apoptotic assays on CD34+ and CD33+ cells showed...
Characterization and modulation of immunoregulatory molecules in neuroinflammation
(2005-01-06)
. The in vitro expression of human TIM-1 and TIM-3 was examined using Th 1 and Th2 cell lines and real time RT-PCR. The ex vivo expression was determined in mononuclear cells derived from peripheral blood (PBMC) and cerebrospinal fluid (CSF-MC) of persons with MS...
Sentinel node biopsy in breast cancer : aspects on validation, diagnostics and lymphatic drainage pattern
(2006-10-06)
with prior intervention were included. The detection rates were 95.3% (710/745) and 90.7% (78/86), respectively. During the follow-up time of almost 2 years, no axillary relapse was found among the 103 patients with a positive SLN that was followed by ALND...
Gene expression profiling in animal models of alcoholism
(2004-11-24)
of regional expression correctly identified several genes known to be preferentially expressed within the Nc. Accumbens, e.g. dopamine D1 and D2, adenosine A2a receptors, and substance P. Analysis of line-specific expression revealed 48 differentially...
Psychosocial risk factors in women with coronary heart disease : stress, social support and a behavioral intervention
(2005-09-16)
randomization, at 10 weeks (after 10 intervention sessions), at 1 year (after completed intervention), and at a follow-up 1-2 years later.
Results: In study I, marital stress was negatively associated to social support, whereas work stress was not associated...
Studies of the novel PDGFs, focusing on PDGF-D
(2006-05-26)
Thirty years ago the classical platelet-derived growth factors (PDG17s), PDGF-A and PDGF-B were discovered. For a long time they were thought to be the only PDG17 isoforms to exist, but recently two novel PDGF molecules ...
Viral zoonoses in Estonia : hantaviruses and tick-borne encephalitis virus : identification, prevalence, serological and genetic relationships
(2006-02-15)
Hantaviruses and tick-borne encephalitis virus (TBEV) cause serious human infections. Hantaviruses are transmitted to humans by wild rodents and cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary ...
Synthesis of indole and oxindole derivates incorporating pyrrolidino, pyrrolo or imidazolo moieties
(2004-11-26)
The focus of this thesis is on the synthesis of oxindole- and indole-derivatives incorporating pyrrolidins, pyrroles or imidazoles moieties.
Pyrrolidino-2-spiro-3'-oxindole derivatives have been prepared in high ...