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Optimization of cyclophosphamide therapy based on pharmacogenetics
(2006-11-03)
catalyzed by cytochrome P450 (CYP) enzymes. The main enzyme in its activation is CYP2B6 that has a polymorphic gene. Several studies have reported high degree of inter- and intraindividual variation in CPA pharmacokinetics.
The aim of this thesis...
Therapeutic myocardial angiogenesis and its pharmacological modulation
(2005-09-30)
independent of the Akt pathway. Hypercholesterolemia and aging are associated with impaired vascular density associated with downregulation of mVEGF, VEGFR- 1, VEGFR-2, eNOS, Akt and upregulation of apoptotic protein p38 MAPK phosphorylation. phVEGF gene...
Infant feeding and allergy in children
(2005-11-04)
of breastfeeding, regular fish consumption and early supplementation of vitamin A and D based in peanut oil or as water-miscible.
A prospective birth cohort (BAMSE) of 4,089 infants was followed for 4 years using parental questionnaires at ages 2 months, 1, 2...
Genetic susceptibility to breast and endometrial cancer
(2004-09-10)
Hormones are central in the carcinogenic process in the breast and in the uterine epithelium. Individual genetically determined variation in the response to hormonal influence may alter susceptibility to breast and endometrial ...
Prevention and treatment of hepatitis B virus infection
(2005-05-06)
-alpha 5 MIU/m2 body surface area subcutaneously three times weekly for 20 weeks and followed up over a 2-year period. Response with seroconversion and HBV DNA loss in serum occurred in two children (genotypes A and D, respectively), both with pre...
Impaired glucose tolerance in ischemic heart disease
(2005-11-18)
(38%). A fasting plasma
glucose (PG) alone failed to identify more than 80% of the patients with
abnormal glucose metabolism in this study. A multiple stepwise regression
analysis revealed an independent and significant association between 2h
PG...
Studies of high mobility group chromosomal protein 1 as a pro-inflammatory cytokine
(2005-05-27)
.
Macrophages from IL-1 receptor type I-/-' (IL-1R1-/-), Toll-like receptor 2 (TLR2-/-) and RAGE -/- mice were used to investigate the role of these receptors in HMGB1 signalling. HMGB 1 led to TNF-alpha and NO production, the phosphorylation of several MAP...
Motivating clinical treatment of obesity : methods, education, supervision and outcome
(2004-11-05)
nearly doubled during the past 20 years and
now totals nearly 500 000. Obesity continued to increase in the Swedish
population between 1996/97 and 2000/01. In economic terms, the direct
health care cost may be approximately 2 % of the total expenditure...
Studies on fat cell function in human obesity and insulin resistance
(2005-09-30)
Enlarged fat cells, due to excess tri-glyceride (TG) stores with increased basal lipolysis (TG breakdown) and blunted action of the major regulatory hormones of fat cell metabolism (catecholamines and insulin) are hallmarks ...
Apoptosis in myelodysplastic syndromes : effects of hemopoietic growth factors
(2004-09-03)
Increased apoptosis of hernatopoietic progenitors is a hallmark of myelodysplastic syndromes (MDS) and results in ineffective hematopoiesis. Erythroid apoptosis is thought to be the main mechanism underlying the severe ...