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Computational exploration of human genome variation
(2004-09-03)
In studies of human genome variation, researchers attempt to identify the DNA sequence differences between our genomes that contribute substantially to variation that can be observed on a physical level (phenotype). Genetic ...
Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Diastolic heart function in hypertension-induced left ventricular hypertrophy
(2006-09-15)
Hypertensive left ventricular (LV) hypertrophy is an independent strong risk factor for cardiovascular morbidity and mortality. An abnormal diastolic relaxation in the absence of systolic impairment is often seen in patients ...
Plasticity in the dopamine 1 receptor system : behavior and cell biological studies
(2004-09-10)
Dopamine is a key neurotransmitter in the brain, and has an important
modulatory role in the control of motor activity and cognitive processes.
Dysfunctions of the dopamine system have been implicated in several
neuro ...
Leukemia chemotherapy : experimental studies on pharmacological optimisation
(2004-11-26)
with the
exception of K562 cells. DNA fragmentation was faster at high DNR
concentrations in all the cells except K562 cells. In leukemic cells from
patients with AML, the time course of DNA fragmentation at 0.25?g/ml
showed large interindividual variations...
Assessment of anti-diabetic effect of Vietnamese herbal drugs
(2005-11-18)
in 150 μM phanoside alone. At 16.7 mM glucose, phanoside-stimulated insulin secretion was reduced in the presence of 0.25 mM diazoxide. In W islets depolarized by 50 mM KCl and with diazoxide, phanoside stimulated insulin release 2-fold at 3.3 mM glucose...
AMP-activated protein kinase : the connection between exercise and type II diabetes
(2004-11-18)
Skeletal muscle insulin resistance is a hallmark feature of Type 2
diabetes. Physical exercise/muscle contraction elicits an
insulin-independent increase in glucose transport and perturbation of
this pathway can bypass ...
Viridans group streptococci septicaemia and endocarditis : molecular diagnostics, antibiotic susceptibility and cinical aspects
(2005-04-27)
, when using rnpB sequencing we also found Streptococcus gordonii and Streptococcus oralis strains in these patients. We found a reduced susceptibility to pencillin in 18 % (MIC ≥ 0.25 μg/ml) of the VGS isolates in 1998-2003, that is lower compared...
Mechanisms of resistance to ciprofloxacin in Neisseria gonorrhoeae
(2006-04-07)
. 125 - 0.25 mg/L. Introduction of alterations in major outer membrane porin, PorB1b, and probably other alterations, in a moderately ciprofloxacin resistant strain (MIC 0.25 mg/L) gave transformants with MICs of ciprofloxacin 0.5-16 mg/L. In one...
Inflammatory status in adolescents : the impact of health determinants such as overweight and fitness
(2006-03-07)
Overweight prevalences are rising among youth and the prevention of associated chronic diseases is priority concern in public health. Inflammatory processes are involved in the pathogenesis of cardiovascular diseases and ...