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Cytoskeletal mechanisms in synaptic vesicle recycling
(2003-01-03)
of reticulospinal synapse, "simple synapse", appeared to be most suitable as an experimental model. The majority had active zones with a diameter of 0.8-1.8 gm. The number of synaptic vesicles in the middle section of serially cut synapses correlated with the active...
Children's testimony
(2002-11-26)
Background: Most cases of child sexual use are identified through statements made by children and in many cases such statements constitute the only evidence available that abuse occurred. Despite its importance the use of ...
Voltage sensor movements in shaker and HCN channels
(2003-11-14)
Voltage-gated ion channels are crucial for electrical signaling in living organisms. They are composed of four similar subunits with six transmembrane α-helices, S1-S6. Each subunit contains a voltage-sensing domain, S1-S4, ...
Neuromechanical control of the spine
(2003-05-23)
Control of the spine is complex. The spine is inherently unstable and dependent on the contribution of muscles. Yet there is considerable redundancy in the motor system with many muscles that act on the trunk.
This ...
Imaging vision : functional mapping of intermediate visual processes in man
(2001-11-15)
The human visual system is highly adept at recognizing objects
independent of changes in viewing conditions, such as viewpoint,
illumination, and partial occlusions by other objects in the visual
environment. This ...
Histochemical, biochemical and electrophysiological studies on dorsal root ganglion cultures : focusing on galanin, neuropeptide Y and glutamate
(2001-11-15)
Galanin (Gal) and neuropeptide Y (NPY) are two peptides, which are
strongly up- regulated in a population of dorsal root ganglion (DRG)
neurons after peripheral nerve injury (axotomy). Both peptides may be
involved in ...
Molecular mechanisms of local anaesthetic action on voltage-gated ion channels
(2004-04-02)
In this thesis I try to clarify some molecular mechanisms of local anaesthetic action on ion channels. The traditional view is that local anaesthetics eliminate action potentials by a direct block of Na channels. Other ...
Regulation and physiological role of tyrosine hydroxylase phosphorylation in the striatum
(2003-02-07)
Tyrosine hydroxylase (TH) catalyses the conversion of tyrosine to DOPA and is the rate- limiting enzyme in the biosynthesis of catecholamines, a group of neurotransmitters involved in various brain functions. Short-term ...
Modulatory effects and interactions of substance P, dopamine and 5-HT in a neuronal network
(2003-04-18)
The spinal neuronal network that generates the locomotor rhythm in lamprey contains excitatory and inhibitory interneurons, reticulospinal inputs from the brainstem, and motor neurons. In this thesis, I have studied how ...
On spinal mechanisms for reflex control in man : modulation of Ia-afferent excitation with changes in muscle length, activation level and fatigue
(2004-03-26)
To control muscle force, neural activation has to take alterations in
muscle mechanics into account. This thesis assesses modulations in
excitatory efficacy of Ia-afferents during muscle length changes at
different ...