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Cytochrome P450 2C9 polymorphism : interindividual differences in drug metabolism and phenotyping methodology
(2002-01-25)
enzyme variant originates from the CYP2C9*1 allele, whereas CYP2C9*2 and CYP2C9*3 code for enzymes with amino acid substitutions R144C and 1359L, respectively. There is accumulating evidence that this genetic polymorphism give rise to clinically important...
Exploring malaria case mangement of underfive children at households and public primary health care facilities in Kibaha district, Tanzania
(2003-10-30)
, interviews using questionnaires were done with heads of households and mothers/guardians in 729 households. Capillary blood samples from 336 children were analysed for CQ and SP using HPLC. Twelve FGDs were carried out with mothers/guardians of under-fives (4...
Risk and resilience in children born preterm : cognitive and executive functioning at 5 1/2 years of age
(2003-11-28)
at the NICU. The test design was the same in the two studies.
The WPPSI-R results of the VLBW children fell well within the normal range: WPPSI-R full scale (FSIQ) 95.7, verbal subscale (VIQ) 99.9 and 91.6 for the performance subscale (PIQ).The term born...
The central role of the CD4 T-helper cell in HIV infection : analysis of cell mediated responses and CCR-5 genotypes in HIV-1 infected individuals
(2001-10-26)
Human immunodeficiency virus (HIV) infection is characterized by
progressive immunologic dysregulation. The main target of HIV is the CD4
cell resulting in malfunction of the immune system, with a decline in CD4
cells ...
Smith-Lemli-Opitz syndrome : a disorder of cholesterol synthesis : diagnosis, treatment and pathogenetic aspects
(2002-09-06)
In 1993 it was first suggested that the Smith-Lemli-Opitz syndrome (SLOS), described almost 30 years earlier as a malformation syndrome, is caused by defective synthesis of cholesterol. Hypocholesterolaemia and accumulation ...
Malignant mesothelioma : an experimental study with emphasis on proteoglycans in mesothelial cell growth and differentiation
(2002-04-17)
Malignant mesothelioma is a highly aggressive tumor with median survival ranging from 4 to 12 months and, despite intense therapeutical efforts, it is invariably fatal. Mesothelioma cells are unique in the sense that they ...
The human placenta : an angiographic study
(2003-04-25)
The arterial vessels from the umbilical cord spreading over the chorion and its cotyledonary branches constitute the main body of the placental vascular tree. In the present study it was visualized by angiography and related ...
Circulating immune complexes in atherosclerotic vascular disease
(2001-08-31)
We have investigated the association of the humoral immune factors
circulating immune complexes (CICs) and autoantibodies against
cardiolipin (aCL) and oxidatively modified LDL (oxLDL) to atherosclerotic
vascular diseases.
In ...
Intoxication of mammalian cells by the cytolethal distending toxin of Haemophilus ducreyi : a novel mechanism of action
(2001-09-14)
The cytolethal distending toxins (CDTs) are a newly described family of
bacterial protein toxins with a novel mechanism of action: DNA damage.
Haemophilus ducreyi produces a cytotoxin that belongs to this family.
This ...
Cat and dog allergens : dispersal, exposure and health effects in childhood
(2002-11-21)
was associated with a reduced risk of sensitisation to airborne allergens other than dog, OR 0.36 (0.15-0.83) and a trend towards lower risk of asthma, OR 0.50 (0.24-1.03). However, there was a selection of pet ownership into the study. Cats were less frequently...