Search
Now showing items 1-10 of 37
Molecular aspects of glutathione synthetase deficiency
(2004-02-27)
The tripeptide glutathione (GSH) is involved in several crucial pathways in the cell, for instance regulation of enzyme activity, DNA synthesis, and free radical scavenging. Synthesis of GSH takes place via two steps in ...
Idiopathic menorrhagia : studies of angiogenesis and surgical therapy
(2003-11-21)
Background: Excessive menstrual bleeding, menorrhagia (i.e. > 80 nil loss of blood) is a com-mon gynecological problem in women of reproductive age, accounting for over 20% of visits to gynecology outpatient clinics. The ...
Medium chain dehydrogenases/reductases : alcohol dehydrogenases of novel types
(2003-10-03)
of the MDR enzymes. Comparisons with the ALDH family have also been included regarding certain patterns recognized through the extensive studies of ADH. ADH3 is of ancient origin, slowly evolving, has a well-defined function and has two segments...
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
quinazolines, a type of heterocyclic compounds that is considered to be highly interesting as scaffolds for development of new drugs. When the acyl halide was a tertiary 2-haloacyl halide, the reaction instead gave 1,4-benzodiazepine-3-ones via rearrangement...
Identification of the common eliminated region (CER1) by the microcell hybrid based 'elimination test'
(2001-11-27)
The aim of elimination test (Et) is to identify tumor antagonizing genes
from chromosome regions that are regularly deleted in microcell hybrid
(MCH) derived tumors through serial SCID mice passages. Et so far was
focused ...
Detection and epidemiologic subtyping of Legionella pneumophilia using DNA-based molecular methods
(2003-11-14)
. For the first time this was proven to be due to a genetic event, which was not reflected in the fingerprinting patterns. The (MAb) 3/1-negative strains thus lacked the lipopolysaccharide associated gene (lag1). Also, for the first time a legionella outbreak...
Subcellular localization and signalling of Brutons tyrosine kinase (Btk)
(2002-11-28)
found that Tec family
kinases bind to caveolin-1, a major structural component of caveolae
(rafts or microdomains) located in the plasma membrane. Finally, we
demonstrate that Cbl acts as an E3-ubiquitin ligase for Btk and that
ubiquitinated Btk...
Diagnostic evaluation of fetal death with special reference to intrauterine infections
(2002-05-10)
-99 according to an extensive investigational protocol. A presumptive explanation of the stillbirth was established in 91% of the cases. The most common factors associated with intrauterine fetal death could be identified as infections (24%), placental...
Studies on autoimmune diabetes in Latvians and other populations
(2001-10-09)
alleles. IDDM is positively associated with HLA DR3 and DR4 in Caucasians. From HLA-DQ molecules, DQ8 (DQA1*0301- DQB1*0302) is the most prevalent IDDM haplotype in Caucasians, followed by DQ2 (DQA1*0201-DQB1*0501). Taken together, DQ8, DQ2 or both account...
Molecular biology of Brouton's tyrosine kinase
(2003-11-14)
and Tec are different. Btk preferentially phosphorylates the SH3 domain of Btk and Bmx, while Itk phosphorylated Itk and Btk SH3 domains, whereas Tec could phosphorylate the SH3 domain of Btk and Tec, but also with reduced efficiency Bmx and Itk...