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Health risk assessment of dioxin-like compounds in complex samples
(2003-10-10)
There are several scientific as well as political and economic reasons why the risk assessment of dioxins in complex samples needs to be further refined. Today, there seems to be no margin of safety between doses that cause ...
Occupational exposure to electromagnetic fields and chronic diseases
(2003-11-21)
This thesis consider two exposures from the electromagnetic spectrum extremely low-frequency magnetic fields (ELF MF) and ultraviolet (UV) radiation. ELF MF are the lowest and UV radiation ranges among the highest frequencies ...
Extremly low frequency magnetic fields and breast cancer
(2003-05-07)
Extremely low frequency magnetic fields (ELF EMF) arise around all electrical leaders and equipment that is ran by electricity. In our modem society basically everyone is therefore to some extent exposed to magnetic fields. ...
From data to decision : a case study of controversies in cancer risk assessment
(2002-11-01)
the chlorinated solvent trichloroethylene (CAS no. 79-01-6). The purpose of the present study is to discuss (1) why risk assessors come to different conclusions, (2) how scientific data are used in risk assessment, and (3) how scientific uncertainty is handled...
Diet and the metabolic syndrome : a cross-sectional study of 301 men from Stockholm County
(2003-11-25)
The metabolic syndrome is a common condition that increases the risk of cardiovascular disease and type II diabetes. It is characterised by a clustering of metabolic disturbances such as abdominal obesity, dyslipoproteinemia, ...
Assignment and assessment of orthology and gene function
(2004-01-30)
Several genomes from different species have been sequenced over the last years, most notably the human genome. An important task of computational biology is to classify and functionally annotate the large amount of sequence ...
Pharmacogenetics of drug metabolizing enzymes with special emphasis on Ethiopians
(2003-02-14)
Pharmacogenetics of drug metabolising enzymes has been well studied in Caucasians and Asians, but relatively little in Africans. The aim of this thesis was to investigate the molecular genetics of drug metabolising enzymes, in particular CYP2D6, CYP...
Long-term outcome of renal transplantation in childhood
(2003-01-31)
The aim of this thesis was to evaluate the long-term results of renal transplantation in children at Huddinge University Hospital, with special reference to outcome. We therefore evaluated the course of events in children ...
Structure and function of hepatic cytochromes P450 : implications for drug development
(2002-11-25)
6 allele (CYP2D6*17) common in Black African populations
carrying three mutations Thrl07IIe, Arg296Cys and Ser486Thr was
investigated by recombinant expression and the enzyme characterized using
CYP2D6 specific substrates. It was found that both...
Adenosine receptor/dopamine receptor interactions : molecular and biochemical aspects
(2002-09-11)
The dopamine receptors have been shown to be involved in a variety of higher brain functions, such as motor control, cognition and affective states. Agonist and antagonists of dopamine receptors are widely used to treat ...