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Drug metabolic capacity in Koreans : CYP2D6 & CYP2C19 pheno- and genotype relationships in healthy volunteers and in patients
(2002-05-24)
.6%) were identified as poor metabolizers with MR of 6.95 or higher. Allele frequencies of CYP2C19*2 and *3 were 21% and 12%, respectively. The distributions of the omeprazole MRs significantly depend on CYP2C19 genotype status (p<0.0001).
One hundred...
Distribution and pathophysiological role of amyloid precursor protein and presenilin 1 : characterization in rats and in vitro studies on the pathogenic arctic mutation
(2002-11-01)
's disease cases. In a few families the disease is caused by pathogenic mutations located on three different genes encoding presenilin (PS) 1, PS2 and APP.
PS is an important component of the complex executing gamma-secretase processing of APP. A detailed...
Studies of presenilin function in neurodegeneration and in human embryonic CNS during development
(2004-05-21)
Presenilin-1 (PS1) and -2 (PS2) gene mutations cause early onset familial
Alzheimer's disease (FAD). Presenilins provide gamma-secretase activity
for cleaving transmembrane proteins such as the amyloid precursor protein
(APP), Notch receptors...
Prognosis in acute myeloid leukemia and influence of monocytic markers : epidemiological, clinical and experimental studies
(2003-04-04)
Registry substantially improved the coverage. The incidence of AML in adults was 5.4 / 105 / year and the median age 69.5 years. 56% had received standard induction treatment, 28% low-dose treatment and 16% no cytostatic treatment. Median survival for all...
Aspects of gastroesophageal reflux and risk for esophageal cancer : an epidemiological approach
(2003-10-24)
association remained in the stratum without stomach atrophy. In contrast, subjects with CagA positive serology had an about 2-fold excess risk for esophageal squamous-cell carcinoma. Compared with the general population, a significant excess risk...
Gait in patients with knee osteoarthritis : effects of preoperative physical therapy and two surgical interventions
(2004-09-16)
Introduction: Knee osteoarthritis is a common joint disease with impact
on all different aspects of health. This thesis will focus on time and
distance measurements of gait and clinical tests in patients with ...
Genetic polymorphism and natural killer cell activity in multiple myeloma
(2002-05-17)
Multiple Myeloma (MM) is a B cell malignancy characterised by an accumulation of clonal neoplastic plasma cells in bone marrow. Its aetiology remains unknown. Remarkable racial differences in the incidence of MM and ...
Development of a new PNA analogue as a potential antisense drug and tool for life-science studies
(2004-05-13)
The work described in this thesis focuses on applying synthetic organic chemistry methods (supported by modem synthesizers and analytical techniques) for the preparation of peptides and modified nucleic acids in order to ...
Studies on HIV-2 antibody mediated neutralisation, coreceptor usage and in vivo tropism
(2001-11-21)
Human immunodeficiency virus type 2 (HIV-2) is the second virus that
causes AIDS in humans. It has a genetic identity with HIV-1 of 40-60% and
similar genetic organisation and biological properties, but the two
viruses are distinguished certain...
Radiologic diagnosis of appendicitis in children
(2004-04-23)
Suspected appendicitis is the most common cause of emergency abdominal surgery in children. Because of the often atypical clinical findings, the diagnosis of appendicitis is difficult and may be delayed. Perforation has ...