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Health risk assessment of dioxin-like compounds in complex samples
(2003-10-10)
There are several scientific as well as political and economic reasons why the risk assessment of dioxins in complex samples needs to be further refined. Today, there seems to be no margin of safety between doses that cause ...
Neuropeptide expression in mouse disease models
(2003-05-07)
The role of neuropeptides and the significance of peptidergic mechanisms in neurodegenerative diseases are still relatively unexplored. In the periphery, nerve injury results in dramatic changes in the expression of ...
Dissection of immunity controlling spread and growth of Listeria monocytogenes in neuronal cells
(2003-11-07)
-incubation of L. monocytogenes-infected PHN with spleen cells from immune (re-infected) but not uninfected or infected animals also reduced the intraneuronal bacteria. This is likely due to direct neuron-T cell interactions. CD4+ and CD8+ T cells were needed...
Molecular mechanisms involved in the growth of human uterine leiomyomas
(2002-11-14)
Human uterine leiomyomas (fibroids) are benign neoplasms arising from uterine smooth muscle cells, and are suggested to be sex steroid dependent. The aim of this study was to investigate the molecular mechanisms by which ...
Studies on proteins involved in the molecular regulation of insulin exocytosis
(2004-02-27)
Type 2 diabetes mellitus is a disease characterized by impaired insulin secretion and insulin resistance. Better understanding of molecular mechanisms of insulin secretion may help to optimize type 2 diabetes management. ...
Radiologic diagnosis of appendicitis in children
(2004-04-23)
Suspected appendicitis is the most common cause of emergency abdominal surgery in children. Because of the often atypical clinical findings, the diagnosis of appendicitis is difficult and may be delayed. Perforation has ...
Effect of pharmacological treatment of serotonergic function in depression
(2002-05-03)
Since its identification in raphe neurons of the central nervous system (CNS), the biogenic amine serotonin (5- hydroxytryptamin, 5-HT) has been implicated in the etiology and pathophysiology of affective disorders, such ...
Identification of the common eliminated region (CER1) by the microcell hybrid based 'elimination test'
(2001-11-27)
The aim of elimination test (Et) is to identify tumor antagonizing genes
from chromosome regions that are regularly deleted in microcell hybrid
(MCH) derived tumors through serial SCID mice passages. Et so far was
focused ...
Technology development for genome and polymorphism analysis
(2003-01-24)
Single nucleotide polymorphism (SNP) is widely expected to provide a multitude of benefits in areas of medical research. There is, however, a growing disparity between the rate of SNP discovery and the development of ...
Diabetic osteopathy : a study in the rat
(2012-03-09)
exhibited endosteal erosion of the diaphyses up to 18% and periosteal expansion up to 8%. The vertebrae and metaphyses of long bones showed a decrease up to 24% in areal bone mineral density (BMD), whereas no decrease was seen in the diaphyses. Cross...