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Student-environment fit for students with physical disabilities
(2002-08-09)
The overall aim of the research presented here was to identify and
explore aspects of the school environment that influence the
participation of students with physical disabilities. The first study
examined the reliability ...
Thioredoxin reductase and selenium in carcinogenesis and multidrug resistance
(2004-05-21)
The thioredoxin system, comprising thioredoxin, thioredoxin reductase (TrxR) and NADPH, is a redox system of great importance in the defence against oxidative stress and is involved in the regulation of several cellular ...
Role of toll-like receptors in host responses to mucosal bacterial infections
(2002-11-15)
Spaetzle is processed by a serine protease, we investigated whether proteases are important for LPS signaling in human cells as well. Three serine protease inhibitors were found to prevent LPS signaling, however, they also inhibited Il-1 beta induced...
Expression of multidrug resistance genes and proteins and effect of selenite in anthracycline-resistant human tumor cell lines
(2004-04-02)
RNA expression and amplification of the multidrug resistance gene (MDR-1). The MDR-1 gene amplification correlated also to the expression levels of the P-glycoprotein. In the doxorubicin resistant U-1285dox900 cells, the resistance correlated with the MRP1 gene...
Clinical pharmacokinetics of intravenous ethanol : relationship between the ethanol space and total body water
(2001-10-26)
Introduction: Total body water (TBW) is an important parameter in
pathological states where the normal regulation of fluid balance is
impaired (e.g., during critical illness, congestive heart failure, bum
injury and ...
G-proteins and adenylyl cyclase in Alzheimer's disease postmortem brain
(2002-01-25)
related to clinical symptoms. Immunoblotting of homogenates from the same tissues revealed a significant decrease in G, in hippocampus, and an increase in the Ca2+/CaM dependent AC isoform 1.
In conclusion, the results presented in this thesis indicate...
Longitudinal studies of human papillomavirus infection : with special reference to screening for cervical cancer and treatment of CIN
(2003-10-03)
. Major determinants of HPV seropositivity were history of another STD and > 20 lifetime sexual partners. Ninety-one women were also followed with repeated testing for a median of 1.9 years. 33-50% of scropositive women reverted to seronegativity...
A reason to be bitter : cassava classification from the farmers' perspective
(2001-11-16)
of bitter
taste of the root tip was a good predictor of cyanogenic glucoside levels
(r = 0.65). Mean cyanogenic glucoside level in 132 roots from "cool"
cultivars was 29 mg HCN eq kg-1 fresh weight (Cl 25-33, range 1 - 123),
and in 360 roots from "bitter...
Physical activity in men and relation to prostate cancer
(2004-05-07)
were studied in relation to (1) age in a cross-sectional setting (Paper II), (2) age in a longitudinal setting and (3) calendar-time (Paper III). In a population-based cohort of 33,466 men aged 45-79 years in central Sweden, we collected information...
Nuclear hormone receptors studied by molecular dynamics computer simulations
(2004-03-05)
Nuclear hormone receptors form a super family of homologous transcription factors. The liganddependent nuclear receptors are important drug targets controlling metabolic and inflammatory disorders, amongst others. The ...