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Endothelial cytoadherence, rosetting and virulence in Plasmodium falciparum malaria
(2001-11-23)
Excessive sequestration of Plasmodium falciparum-infected erythrocytes (pRBC) and uninfected erythrocytes directly blocks the microcirculation and precipitates severe symptoms from the affected organ and is thereby thought ...
Molecular and diagnostic aspects of the protein p41 of HHV-6 and silencing of the CD46 receptor by RNA interference
(2003-05-23)
Multiple sclerosis (MS) is one of the most common diseases of the central nervous system (CNS), leading to sensory and motor disability in young adults. There is no efficient treatment of the disease. Its etiology is ...
Endocrine tumour development : with special focus on chromosome arms 1p and 11q
(2002-03-29)
carcinoids (67%), and 1 cen-p31 in both pheochromocytomas and abdominal paraganglioms (82%). Aberrations of chromosome 18 in midgut carcinoids seem to be an early event together with loss of 11 q22-23, whereas loss of 16q21-qter and gain of 4p14-qter...
Recombinant mucin-immunoglobulin chimeras as xenoreactive anti-pig antibody absorbers
(2002-08-16)
characteristic of a heavily glycosylated protein. Following coexpression of the porcine alpha1,3 galactosyltransferase, the mucin/Ig stained strongly with the alpha-Gal specific lectin Griffonia simplicifolia 1 IB4 in Western blot experiments. The carbohydrate...
Incidence and interval breast cancers in retrospective assessment
(2003-08-08)
The aims of this thesis were to investigate how different review methods used for radiological classification of breast cancers would affect the proportion judged to be false negative, to investigate how computer aided ...
Cloning and characterization of canine sulfotransferases
(2003-10-10)
Sulfation generally leads to an increase in hydrophilicity facilitating increased excretion of conjugated molecules. In addition, sulfation has an important role in the synthesis, metabolism and regulation of steroid ...
Development of a new PNA analogue as a potential antisense drug and tool for life-science studies
(2004-05-13)
The work described in this thesis focuses on applying synthetic organic chemistry methods (supported by modem synthesizers and analytical techniques) for the preparation of peptides and modified nucleic acids in order to ...
Diagnostic evaluation of fetal death with special reference to intrauterine infections
(2002-05-10)
The incidence of intrauterine fetal death (>=28 gestational weeks) is approximately 4/1000 births in Sweden. In order to arrive at a potential cause of death, a number of investigations have been recommended in the diagnostic evaluation...
Vestibular control of body orientation in lamprey
(2004-03-26)
Maintenance of body orientation (postural control) is a vital motor function of the brain. The general goal of this project was to understand the organization and operation of neuronal networks responsible for postural ...
Genetic dynamics of HIV-1 : recombination, drug resistance and intrahost evolution
(2004-05-14)
A striking characteristic of HIV is the enormous capacity of genetic
variation. Frequent mutations, deletions, insertions and recombination
events create a population of genetically related but non-identical
viruses ...