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NF-kB in epidermal signal transduction and tumor development
(2002-11-15)
The transcription factor NF-kappaB has been extensively studied since its discovery. NFkappaB has been shown to be invoved in many cellular processes in many different cell types. However, its functions in skin physiology ...
The rhomboid family of intramembrane proteases, conserved regulators of cell communication
(2004-05-14)
The development of multicellular organisms relies heavily on cell
communication. Cells send and receive complex sets of signals,
harmonising their growth and differentiation with that of other, often
distant, cell ...
Synthesis of indolocarbazoles, bisindoles and related sulfur containing systems
(2002-01-28)
transformation into two
different conformers on dissolution in warm strongly polar solvents. In
addition, the elusive [1,2]dithiino[4,3-b:5,6-b']diindole was isolated as
a N,N- dimethylacetamide solvate, the structure of which was rigorously
confirmed by X...
The diagnostic performance of prostate-specific antigen (PSA) in early detection of prostate cancer : considerations of sensitivity, specificity, lead-time and survival
(2003-09-19)
Background: Prostate cancer (PC) is the most common form of cancer, as well as the single major cause of cancer-related mortality among Swedish males. Recent reports indicate that screening of the serum levels of ...
Molecular mechanisms of gene activation by nuclear receptors and their associated coregulators
(2001-10-26)
such coactivators are the TRAP220 and the TIF2, which both contain conserved LXXLL NR interaction motifs (L, leucine; X, any amino acid), so called NR-boxes. Although they utilize the same motifs for binding to NRs, they have been shown to be components of distinct...
Estrogen receptor b in the urogenital tract of both male and female
(2002-05-24)
The central finding of this thesis is that estrogen receptors regulate androgen receptor expression: ERalpha unpregulates AR and ERbeta down-regulates AR. With this theme, we explored the physiological role of an ER-AR ...
Molecular factors relevant to the radiosensitivity of human tumours
(2003-05-16)
the efficiency of repair of SSBs generated by low (X-ray)- and high (nitrogen ions)- LET (linear energy transfer) radiations. High-LET irradiation has been shown to result in a higher proportion of locally multiply damaged sites (LMDSs) compared to low...
Modelling biomolecular interactions
(2003-05-16)
Computational approaches for understanding and aiding in molecular biology has increased in significance over the last decades, where a wealth of biochemical experiments have provided a solid ground for developing computer ...
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
products were more or less complex 1,3-benzoxazinones, one of which required X-ray crystallography confirm its structure. During the work on preparation of N-substituted derivatives of Aa, necessary for synthesis of 1,4-benzodiazepine-3,5-diones...
Molecular biology of Brouton's tyrosine kinase
(2003-11-14)
X-linked agammaglobulinemia (XLA) is caused by an arrest in the B lymphocyte differentiation. XLA patients lack mature B-cells and subsequently antibody production. The defective gene causing XLA is the BTK gene, which codes for the protein Bruton...