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Sarcoidosis : inflammatory mechanisms and markers of activity
(2002-10-25)
Sarcoidosis is a disease characterized by an accumulation of CD4+ T-lymphocytes in affected organs. Previous findings of an association between the HLA-allele DR17 and an accumulation in bronchoalveolar lavage fluid (BALF) ...
Functional analysis of ATM with relevance for primary immunodeficiency and tumor formation
(2004-04-08)
Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by cerebellar degeneration with ataxia, ocular and cutaneous telangiectasias, radiosensitivity, chromosomal instability, immunodeficiency, and ...
Health care financing in China : equity in transition
(2002-08-12)
The aim of the thesis is 1) to assess equity in the provision, financing and utilization of health services in the study counties, after the launching of the Chinese health reform, in relation to income and health status, ...
Promoting suicide prevention : an evaluation of a programme for training trainers in psychiatric clinical work
(2003-09-29)
The overall goal of this thesis is to evaluate a 200-hour academic postgraduate educational intervention programme in suicide prevention at Karolinska Institute developed and implemented by the Swedish National Centre for ...
The prognostic significance of uPA, uPAR an d the cytokine IL-1-alpha in urinary bladder cancer
(2002-03-22)
Tumor invasion and metastasis are the major causes of cancer-related
death. Proteases are important for the invasive and metastatic
propensities of tumors. We have studied the mechanism underlying
endogenous expression of ...
Molecular changes in the tumour suppressor genes p53 and CDKN2A/ARF in human urinary bladder cancer
(2002-01-25)
Urinary bladder neoplasm is the ninth most common cancer in Europe and the United States. The incidence in Sweden is approximately 32 for men and 9 for women per 105 subjects and year and almost all cases are transitional cell carcinoma (TCC). Many...
DARPP-32 in the striatum : multiple regulation and physiological role
(2001-08-24)
Protein phosphorylation is an important mechanism involved in
intracellular signal transduction. The activity of many proteins is
affected by their state of phosphorylation, which in turn is determined
by the combined ...
Autoimmune markers in autoimmune diabetes
(2003-12-19)
Type 1 diabetes mellitus (T1DM) is an autoimmune disease, characterized by autoimmune mediated loss of insulin secreting Beta-cells. The disease is associated with certain HLA class 11 haplotypes. HLA DR3-DQ2 and DR4-DQ8 ...
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
Anthranilic acid (2-aminobenzoic acid, Aa) is the biochemical precursor to the amino acid tryptophan, as well as a catabolic product of tryptophan in animals. It is also integrated into many alkaloids isolated from plants. ...
Malignant mesothelioma : an experimental study with emphasis on proteoglycans in mesothelial cell growth and differentiation
(2002-04-17)
Malignant mesothelioma is a highly aggressive tumor with median survival ranging from 4 to 12 months and, despite intense therapeutical efforts, it is invariably fatal. Mesothelioma cells are unique in the sense that they ...