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Nuclear compartmentalization of viral and cellular proteins involved in gamma-herpes virus (EBV and HHV-8) mediated cellular transformation
(2003-11-07)
The aim of the work described in this thesis has been to characterize the nuclear compartmentalization of cellular and viral proteins involved in EBV or HHV-8 mediated cellular transformation. We have studied the EBV encoded EBNA-5 and its...
Studies on oxysterols : origins, properties and roles
(2003-09-05)
Oxysterols are derivatives of cholesterol present at low concentrations in a variety of physiological compartments. The major oxysterols in human circulation are formed from pools of cholesterol that may be distinguished ...
Gait strategy in myelomeningocele : movements, mechanics and methods
(2003-09-26)
The overall aim of this thesis was to describe the movement patterns employed in self-ambulatory children with a range of muscle paresis due to nervous tissue damage resulting from myelomeningocele, a common congenital ...
Thrombin activatable fibrinolysis inhibitor (TAFI) in different hemorrhagic and thrombotic conditions
(2003-05-13)
Until recently the coagulation and fibrinolytic systems were usually considered as separate entities. Accounts of a fibrinolysis inhibitor that is generated by thrombin shed more light on this field and changed the concept ...
Affective disorders in a stress-vulnerability perspective : a clinical, biological and psycho-social study
(2002-11-15)
positive family history of affective illness, compared to those without a family history. Furthermore, bipolar patients with heredity, had less life events at onset. Bipolar patients with preceding life events had a 4.8-year higher onset, compared to those...
Lower limb ischemia in women
(2004-02-27)
Arteriosclerosis is a general disease affecting different parts of the arterial system. In coronary heart disease (CHD) women have different risk factors, symptoms, indication for treatment, interpretation of diagnostic ...
Drug treatment in children with focus on off-label drug use
(2010-08-06)
There is a lack of paediatric documentation concerning efficacy and
safety of many drugs, which contribute to drug use outside the terms of the product license (off-label). In the present thesis, four studies (I-IV), using ...
Physical activity in men and relation to prostate cancer
(2004-05-07)
Physical activity is hypothesized to reduce the risk of several chronic diseases and enhance longevity. Low levels of activity have been associated with some but not all types of cancers. Although an association with ...
On age related changes in axons and glia of the central nervous system
(2002-08-09)
A growing body of evidence shows that phenotypic changes including axon aberrations, rather than loss of neurons, account for behavioral impairments during aging. The present thesis was undertaken to investigate the ...
Cataract from ultraviolet radiation
(2001-11-09)
Cataract is the major cause of low vision and blindness in the world.
Epidemiological and experimental studies link cataract to (solar)
ultraviolet radiation (UVR) exposure. Current safety limits of UVR
exposure are based ...